Full Description
Brain Energy Metabolism in Alzheimer's Disease - Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer's disease and related disorders.
Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular-glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.
Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.
Contents
Part B
Role of ESCRT Pathway and Autophagy in Neurodegenerative Diseases
Bioenergetic Impairment-Induced Tau Acetylation: Converging Pathways in Alzheimer's Disease
Insulin Resistance and Obesity: Drivers of Energy Crisis for Alzheimer's Disease
Therapeutic Targeting of Brain Bioenergetics in Alzheimer's Disease: Addressing Insulin Resistance, Glucose Hypometabolism, and Mitochondrial Dysfunction
Neurovascular-Glia Crosstalk in the Alzheimer's-Delirium Nexus: Molecular Mechanisms and Therapeutic Repurposing
Genetic and Epigenetic Complexity of Parkinson's Disease: From Dopamine Pathways to Estrogen Interplay
Metallospecies and Their Biological Functions in Alzheimer's Disease
Liquid-Liquid Phase Separation of Tau in Alzheimer's Disease
Noncoding RNA and Receptor Tyrosine Kinase-Mediated Regulation of Brain Energy Metabolism Dysfunction in Alzheimer's Disease
Activation of Nrf2 Neuroprotective Pathways for Treatment of Parkinson's Disease: A State-of-the-Art Review
Metabolic Drivers of Alzheimer's Disease Pathogenesis: Impairments in Glucose Utilization, Lipid Homeostasis, and Alternative Substrate Metabolism
Glial Molecular Signatures as a Liquid Biopsy Marker in Alzheimer's Disease Diagnosis
