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Full Description
Chemoresistance in Glioblastoma: Understanding and Management gives clear insights into the detailed characteristic aspects of glioblastoma disease and the different therapeutic targets that are employed in reducing resistance to chemotherapeutic agents. The book delves deep into the root causes of multidrug resistance and the quest for novel molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, and tumor suppressor genes. In addition, it gives insights on the pathological and molecular features of glioblastoma and the role of cancer stem cells in the resistance to chemo and immunotherapy.
While designed as a comprehensive guide, the book also serves as a valuable reference for professionals seeking to deepen their understanding, refine their skills, and explore new avenues within chemoresistance.
Contents
1. A comprehensive outline of glioblastoma and molecular chemotherapy
2. Brain tumours: diagnosis and treatment
3. Pathological and Molecular Features of Glioblastoma
4. Molecular Mechanisms Underlying Treatment Resistance in Glioblastoma and current therapies
5. Cell Cycle Arrest and Apoptosis in Glioblastoma
6. Variability in Natural Invasion of Tumor Cells Patterns in Human Glioblastoma
7. Epigenome in Gliomas: Novel Targets for Therapy
8. Adaptation of Mitochondria in Drug Resistance of Cancer: Frequency, Mechanisms, and Control
9. Immunotherapy resistant glioblastoma.
10. Dynamics of glioblastoma chemotherapy in blood-brain barrier.
11. Cancer stem cells in resisting chemotherapy and the recurrence of glioblastoma multiforme
