Cell Free Synthesis of Biologics : A Comprehensive Guide

個数：

予約

Cell Free Synthesis of Biologics : A Comprehensive Guide

Niazi, Sarfaraz

ウェブストア価格 ¥46,618（本体¥42,380）
Academic Press Inc（2026/09発売）
外貨定価 US$ 200.00
ポイント 423pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 514 p.
言語 ENG
商品コード 9780443332715

Full Description

Cell Free Synthesis of Biologics: A Comprehensive Guide addresses the need for efficient production methods in biopharmaceutical manufacturing. As the demand for biologics continues to rise, traditional cell-based production systems often fall short due to high costs and complexity. This book offers a detailed exploration of cell-free protein synthesis (CFPS), providing researchers and professionals with the latest methodologies, best practices, and troubleshooting strategies necessary for successful implementation. The content is structured into comprehensive chapters that cover the historical development, technical foundations, optimization strategies, advanced technologies, and the regulatory landscape surrounding CFPS.

Each section is designed to guide users through the complexities of establishing and scaling up cell-free systems, ensuring a clear understanding of the processes involved and the potential applications in therapeutic development, diagnostics, and industrial biotechnology. This book provides pharmaceutical scientists and pharma manufacturing professionals with practical insights and innovative strategies to enhance efficiency and reduce costs in biopharmaceutical production.

Part I: Introduction and Historical Development
1. Introduction to Cell-Free Protein Synthesis
2. Historical Evolution of Cell-Free Systems

Part II: Technical Foundations and Optimization Strategies
3. Optimization of Cell Extract Preparation
4. Biochemical Foundations of Cell-Free Systems
5. DNA Template Design and Genetic Optimization
6. Reaction Condition Optimization
7. Extract Preparation Methodologies

Part III: Advanced Technologies and Innovations
8. Engineering the Cell-Free Environment
9. Incorporating Non-Standard Amino Acids
10. Membrane Protein Synthesis

Part IV: Scale-Up, Process Implementation, and Automation
11. Scale-Up Strategies
12. Industrial Scale Process Design
13. Quality Control and Analytical Methods
14. Downstream Processing and Purification

Part V: Applications and Product Development
15. Therapeutic Proteins and Biologics
16. Industrial Enzymes and Catalysts
17. Diagnostic and Research Tools

Part VI: Regulatory, Compliance, and Commercial Landscape
18. Regulatory Considerations
19. Documentation and Compliance
20. Intellectual Property Landscape
21. Economic Analysis and Business Models

Part VII: Future Directions and Emerging Technologies
22. Emerging Technologies in Cell-Free Synthesis
23. New Product Opportunities
24. Collaboration, Data Sharing, and Knowledge Transfer
25. Vision for the Future of Protein Manufacturing