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Full Description
Enzymes of Polyamine Metabolism, Volume 715 highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Convergence of MYC and the hypusine circuits in the control of metabolism, HDAC10 structure and enzymology, TR-FRET Assay for Profiling HDAC10 Inhibitors and PROTACs, Polyamine Transport Inhibitors: Methods and caveats associated with measuring polyamine uptake in mammalian cells, Evaluation of platinum drug toxicity resulting from polyamine catabolism, Measurements of acrolein adducts resulting from polyamine catabolism, Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: implications for gastric inflammation and carcinogenesis, and much more.
Other sections delve into Molecular and biochemical analysis of eIF5A, Analysis of in vivo SMOX activity, Structure and role of ATP13A2 in polyamine transport, Analysis of Translational Regulation Using Polysome Profiling and Puromycin Incorporation, Targeting polyamine metabolism in an ex vivo prostatectomy model, Development and characterization of a Drosophila model of SRS, Monitoring ODC activity and polyamines in Bachmann-Bupp syndrome patient biological samples, Gene replacement therapy to restore polyamine metabolism, Investigation of polyamine metabolism in bone homeostasis, Collection, preparation, and biobanking of clinical specimens for polyamine analysis, and many other topics.
Contents
1. Convergence of MYC and the hypusine circuits in the control of metabolism
John Cleveland
2. HDAC10 structure and enzymology
David W. Christianson
3. TR-FRET Assay for Profiling HDAC10 Inhibitors and PROTACs
Aubry K. Miller, Raphael R. Steimbach, Kim Remans, Nikolas Gunkel and Peter Sehr
4. Polyamine Transport Inhibitors: Methods and caveats associated with measuring polyamine uptake in mammalian cells
Otto Phanstiel IV
5. Evaluation of platinum drug toxicity resulting from polyamine catabolism
Kamyar Zahedi
6. Measurements of acrolein adducts resulting from polyamine catabolism
Keiko Kashiwagi
7. Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: implications for gastric inflammation and carcinogenesis
Keith Tucker Wilson
8. Molecular and biochemical analysis of eIF5A
Thomas Dever
9. Analysis of in vivo SMOX activity
Cassandra Holbert
10. Structure and role of ATP13A2 in polyamine transport
Ken Lee
11. Analysis of Translational Regulation Using Polysome Profiling and Puromycin Incorporation
Teresa Mastracci
12. Targeting polyamine metabolism in an ex vivo prostatectomy model
Dominic J Smiraglia
13. Development and characterization of a Drosophila model of SRS
Rong Grace Zhai
14. Monitoring ODC activity and polyamines in Bachmann-Bupp syndrome patient biological samples
Andre S. Bachmann, Elizabeth VanSickle and Caleb Bupp
15. Gene replacement therapy to restore polyamine metabolism
Dwi Kemaladewi
16. Investigation of polyamine metabolism in bone homeostasis
Fernando Fierro
17. Collection, preparation, and biobanking of clinical specimens for polyamine analysis
Elizabeth VanSickle, Caleb Bupp and Andre S. Bachmann
18. HPLC analysis of polyamines and their derivatives: an update
Robert Casero Jr. and Tracy Murray Stewart
19. Cell-based assays of HDAC10 polyamine deacetylase activity
Tracy Murray Stewart
20. Drosophila melanogaster Imaginal Disc Assays to Study the Polyamine Transport System
Shannon Nowotarski
21. A Fluorescence-Based Assay for Measuring Aminopropyltransferase Activity
Choukri Ben Mamoun
22. The role of Arginase and polyamines in wound healing and skin differentiation
Leah Anne Vardy
23. Regulation of ODC by antizyme and antizyme inhibitor ?
Senya Matsufuji
24. Polyamine metabolism and transport in gut microbes
Shin Kurihara
25. Methylated polyamines derivatives and antizyme-related effects
Alex Khomutov
26. Novel LC-MS/MS Assay to Quantify D,L-alpha-difluoromethylornithine (DFMO) in Mouse Plasma
Thomas Dowling and Andre S. Bachmann
27. Isobutyl chloroformate derivatization of polyamines for LC-MS quantitation
Ryan Sheldon, Christine Isaguirre, Megan Gendjar, Kelsie Nauta and Nick Burton
