PACAP : From Discovery to Function (Molecular Mediators in Health and Disease: How Cells Communicate)

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PACAP : From Discovery to Function (Molecular Mediators in Health and Disease: How Cells Communicate)

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  • 製本 Paperback:紙装版/ペーパーバック版／ページ数 500 p.
  • 言語 ENG
  • 商品コード 9780443290541
  • DDC分類 571.6

Full Description

PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.

Contents

I. Introduction

II. Pituitary adenylate cyclase-activating polypeptide
1. Discovery and biochemical properties of PACAP (Secondary structure of PACAP, Structure of the PACAP precursor and post-translational processing)
2. Cloning and phylogenetic evolution of the PACAP gene
3. Development of PACAP peptidic analogs for structure-activity characterization
4. Development of PACAP small molecule agonists / antagonists for therapeutic applications III. PACAP receptors
5. Pharmacological, Biochemical and Signaling characterization of PACAP receptors
6. Cloning and phylogenetic evolution of PACAP receptors IV. Expression of PACAP and its receptors
7. Distribution of PACAP and its receptors in the central nervous system (at adulthood and during development)
8. Distribution of PACAP and its receptors in peripheral organs (at adulthood and during development)
9. Presence of PACAP in biological fluids
10. Expression and functional implication of PACAP and its receptors in tumor cells V. Biological actions of PACAP in normal and pathological conditions A. Actions of the CNS
11. Actions on the hypothalamus
12. Actions of PACAP on the pineal gland and circadian rhythms
13. Actions on glial cells
14. Effects of PACAP on the pituitary gland
15. PACAP transport across the BBB and therapeutic implication
16. Neurotrophic actions during development and protective effects in acute brain injuries (stroke and spinal cord)
17. Protective effect of PACAP in neurodegenerative diseases
18. PACAP in migraine
19. Action of PACAP in the central regulation of energy homeostasis, including food intake
20. Behavioral actions of PACAP
21. PACAP and stress
22. PACAP and pain
23. PACAP and psychiatric disorders B. Actions on peripheral organs
24. Effects of PACAP on the eye
25. Effects of PACAP on the thyroid gland
26. Effects of PACAP on the gonads
27. Effects of PACAP on the adrenal gland
28. Effects of PACAP on the gastrointestinal tract
29. Effects of PACAP on the liver
30. Effects of PACAP on the pancreas
31. Effects of PACAP on the respiratory system
32. Effects of PACAP on the cardiovascular system
33. Effects of PACAP on immune cells
34. Effects of PACAP on bones