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Full Description
Epigenetic Regulations in Gastrointestinal Cancers offers a comprehensive exploration of the genomic and epigenomic alterations that underpin the aggressive nature of gastrointestinal (GI) cancers. . By synthesizing the latest research and insights into the role of the tumor microenvironment and cellular signaling pathways, this book aims to elucidate the multifaceted nature of GI cancer neoplasia and propose innovative therapeutic strategies. Addressing critical challenges in GI cancer research and treatment, this book serves as a vital resource for researchers and clinicians striving to bridge the gap between basic research and clinical application. It tackles the complexities of GI cancer mechanisms by integrating knowledge from diverse fields, thereby providing a holistic understanding essential for effective therapeutic development. Through real-world case studies and expert contributions, the book highlights successful treatment regimens that leverage epigenetic insights, thereby fostering dialogue among multidisciplinary teams and promoting collaborative approaches to cancer care. Moreover, the book emphasizes the importance of staying abreast of rapid advancements in the field of cancer research. With contributions from leading experts and an accompanying online platform featuring interactive resources, readers will have access to the latest insights and developments in GI cancer research. By identifying specific epigenetic targets and innovative strategies for overcoming treatment resistance, this book aspires to enhance patient outcomes in GI cancers and contribute to the ongoing evolution of personalized medicine in oncology.
Contents
A. Introduction to epigenetics changes in GI cancers
1. Basics of epigenetics in various GI cancers
2. Overview of epigenetic changes in cancer related to GI system
3. DNA methylation
4. Histone modifications
5. Non-coding RNAs
6. Silencing of tumor suppressor genes
7. Activation of oncogenes
8. Genomic instability
9. Tumor heterogeneity
10. Desmoplastic environment
B. Role of epigenetics in tumor progression and influences on therapy resistance
11. Evasion of apoptosis
12. Promotion of angiogenesis
13. Stimulation of metastasis
14. Activation of alternate signaling pathways
15. Epigenetic modification in cancer stem cell (CSC) in GI cancers
16. Mechanisms of drug resistance
17. Immune Evasion
18. Epigenetic alterations in treatment response
19. Strategies for overcoming resistance
C. Exosomes and epigenetic regulation
20. Role of exosomes in GI cancers
21. Impact on tumor microenvironment
22. Exosome-derived biomarkers and therapies
D. Current and Emerging Epigenetic Therapies and Future Directions
23. Epigenetic biomarkers and scientific evidence
24. Epigenetic drugs
25. Challenges and opportunities in epigenetic therapy
26. Emerging trends in epigenetic clinical research
27. Integrating epigenetics with other GI cancer treatments
