Full Description
Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions provides an in-depth study of the elements that accelerate aging, exploring how biological, genetic, and environmental factors affect cellular and systemic homeostasis, leading to accelerated aging. This book fills a significant gap in the existing literature by offering a comprehensive analysis of genetic, environmental, and lifestyle variables that contribute to aging, making it an invaluable resource for scholars, medical professionals, and decision-makers. The book begins with a historical perspective on biological aging and its effects on health and society, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not contribute to accelerated aging. Subsequent chapters explore the basic concepts and key accelerators in human biology, the role of biological clocks, and the mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction. The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator. Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life. It is an essential resource for scientists, researchers, and clinicians seeking to understand accelerated aging mechanisms and develop strategies to enhance longevity and improve overall health.
Contents
1. Aging: Concept of Biological Aging, Historical Perspective, and Impact of Aging on Health and Society
2. Hallmarks of Aging: Exhibiting Characteristics That May or May Not Contribute to Accelerated Aging
3. Aging Accelerators: Basic Concept, Key Accelerators in Human Biology, and Molecular Basis of Aging Accelerators
4. Biological Clocks and Accelerated Aging: Understanding the Timers of Life
5. Mechanisms of Aging Accelerators: Cellular Senescence, DNA Damage, Epigenetic Changes, Mitochondrial Dysfunction, and Stem Cell Exhaustion
6. Diverse Timelines: How Different Organs Age at Different Rates
7. Accelerated Aging: The Brain's Role as the Body's Aging Integrator
8. Oxidative Stress: How It Accelerates Aging
9. Obesity Accelerates Aging
10. Chronic Inflammation as an Accelerator of Aging
11. Stress, Anxiety Disorder, and Depression Accelerate Aging
12. Physical and Environmental Factors Accelerate Aging
13. Role of Socioeconomic, Social, Demographic, and Biological Factors in Accelerating Aging
14. Dietary and Lifestyle Factors Accelerate Aging
15. Mitogenic Factors Accelerate Aging
16. Vitamin D Deficiency as Potential Factor to Accelerate Aging
17. Pharmacological and Nutraceutical Interventions to Prohibit Accelerated Aging
18. Lifestyle Modification and Dietary Supplements to Prevent Accelerated Aging
19. SIRTain Regulators of Accelerated Aging
20. Regenerative Medicine and Genetic Therapies as Regulators of Accelerated Aging
21. Current Research Trends, Emerging Technologies, and Future Directions for Prevention of Accelerated Aging
