Full Description
Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.
The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.
This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.
Contents
SECTION 1: Delivery challenges and opportunities
1. Introduction and impact statement
2. Challenges and opportunities in targeted delivery
SECTION 2: Delivery barriers
3. Blood—tumor barriers
4. The blood—brain barrier
5. Overcoming ocular barriers for effective drug delivery
6. Pulmonary barriers to targeted delivery
7. Exploiting gastrointestinal barriers for targeted drug delivery
8. Cellular and intracellular barriers for drug delivery
SECTION 3: Endogenous targeting strategies
9. Overview of endogenous targeted delivery strategies
10. Endogenous pH alterations for precision drug delivery
11. Hypoxia responsive delivery systems
12. Redox-responsive micellar drug delivery systems
13. Nutrient transporter-targeted drug delivery
14. Glyco-targeted delivery systems
15. Surface-modified delivery systems for stealth function
SECTION 4: Drug conjugates
16. Therapeutic exploitation of the neonatal Fc receptor in albumin-based drug designs
17. Lectin conjugates for targeted delivery
SECTION 5: Protein corona-enabled delivery
18. Overview of protein corona formation and implications
19. Protein corona-mediated targeted delivery
20. Protein corona—enabled cloaking systems for drug delivery
21. Harnessing the protein corona for brain targeted delivery
SECTION 6: Cell-based drug delivery
22. Stem cell-based drug delivery system
23. Leukocyte-targeting drug delivery systems
24. Large peritoneal macrophage tropism for targeted delivery
25. Neutrophil-based drug delivery systems
26. Erythrocyte-based delivery
27. Platelet-based drug delivery systems
SECTION 7: Cellular "backpacks"
28. Cellular backpacks as drug delivery systems
29. Immune cell backpacks
30. Red blood cell as a hitchhiking platform for targeted systemic drug delivery
SECTION 8: Extracellular vesicles
31. Extracellular vesicle journey: Cellular secretion, communication, and functions
32. Extracellular vesicles for targeted delivery
33. Surface-engineered extracellular vesicles
34. Role of bacterial extracellular vesicles in health and diseases
SECTION 9: Viral particles for targeted delivery
35. Engineered viral vectors as tools for therapeutic gene delivery
36. Targeted delivery using virus-like particles
37. Engineered plant viruses
SECTION 10: Clinical Translation--Challenges and Opportunities
38. Manufacturing of complex pharmaceuticals
