Full Description
Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacological
properties of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the scientific pathways when developing new drugs. This makes the book especially relevant for senior university students majoring in pharmaceutical sciences as well as graduate students and researchers.
Contents
1. Medicinal chemistry and process development of the type 2 diabetes drug sitagliptin
2. The developmental history of insulin pharmaceuticals
3. The developmental trajectory of GLP-1 receptor agonists
4. Antidiabetic drugs based on sodium-glucose cotransporter 2 inhibitors
5. Cholesterol-lowering drug atorvastatin
6. Angiotensin II receptor antagonists for treatment of hypertension: the discovery of losartan and its analogs
7. Antithrombotic drug—apixaban
8. Development of the anticoagulant drug fondaparinux sodium
9. Development of the nucleotide antiviral drug sofosbuvir for the hepatitis C virus
10. The first HIV-1 integrase inhibitor, raltegravir
11. Discovery and development of the human immunodeficiency virus protease inhibitor Saquinavir
12. Baloxavir: an antiinfluenza drug with a novel mechanism of action
13. Paclitaxel: a natural antitumor agent
14. Antitumor drug eribulin
15. Targeted protein kinase inhibitor imatinib
16. A case study of the irreversible covalent epidermal growth factor receptor (EGFR) inhibitor—afatinib
17. Medicinal chemistry and process development of the antibreast cancer drug tamoxifen
18. Triazole antifungal drug—fluconazole
19. Discovery of the antibacterial drug Linezolid and its synthetic technology research
20. Carbapenem antibiotic meropenem
21. Antiparasitic drug praziquantel
22. A case study on the proton pump inhibitor omeprazole
23. The inhibitors of phosphodiesterase type 5A effectively treat erectile dysfunction
24. GABAA receptor agonists: discovery of the general anesthetic propofol and its analogs
25. The discovery of risperidone: a case of multiple target antipsychotic drug
26. A case study on the first-in-class antirenal anemia drug roxadustat
27. Function, pharmaceutical, and pharmacological research and development of natural tetracyclic dipyranocoumarin (1)-calanolide A and its analogs
28. Bisphosphonates: a targeted therapeutic medication for skeletal system
29. Celecoxib targets cyclooxygenase in nonsteroidal antiinflammatory drugs
30. Case study of antisense oligonucleotides for duchenne muscular dystrophy
