Personalized Epigenetics (Translational Epigenetics) （2ND）

Tollefsbol, Trygve (EDT)

Academic Press Inc（2024/07発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 780 p.
• 言語 ENG
• 商品コード 9780443238024
• DDC分類 616.99

Full Description

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Contents

Section I. Overview
1. Epigenetics of Personalized Medicine

Section II. Epigenetic variations Among Individuals
2. Interindividual Variability of DNA Methylation
3. Differences in Histone Modifications Between Individuals
4. Individual Noncoding RNA Variations
5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation
6. Limitations of Personalized Epigenetic Variation Comparisons

Section III. Technologies for Personalized Epigenetics
7. Personalized Epigenetics Technologies
8. Computational Methods in Epigenetics

Section IV. Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine
9. Epigenetic Biomarkers in Personalized Medicine
10. Epigenetic 'Fingerprint'
11. Epigenetics of Personalized Toxicology

Section V. Environmental Personalized Epigenetics
12. Environmental Contaminants and Their Relationship to the Epigenome
13. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

Section VI. Pharmacology and Drug Development of Personalized Epigenetics
14. Personalized Pharmacoepigenomics
15. Epigenetics of Personalized Nanomedicine
16. Personalized Medicine and Epigenetic Drug Development

Section VII. Personalized Epigenetics of Disorders and Disease Management
17. Understanding Interindividual Epigenetic Variations in Obesity and Its Management
18. Personalized Epigenetic Management of Diabetes
19. Epigenetics and Personalized Pain Management
20. Epigenetic Modification of miRNAs in Cancer
21. Epigenetics and Chemoresistance: A Personalized Approach to Cancer Therapy
22. Personalized Epigenetics and Neurological Disorders
23. Managing Autoimmune Disorders through Personalized Epigenetic Approaches
24. Cardiovascular Diseases and Personalized Epigenetics

Section VIII. Challenges and Future Directions
25. Future Challenges and Prospects for Personalized Epigenetics