Full Description
The Handbook of Parkinson's Disease Mechanisms offers an integrated overview of the fundamental research devoted to understanding its causes and mechanisms, highlighting recent advances and clinical significance. With a strong focus on cellular and animal model studies, this book also examines the etiology, pathophysiology, epidemiology and underlying symptoms of Parkinson's disease.
Written with an interdisciplinary approach, this book provides thorough research that will be of interest to researchers, clinicians and graduate students interested in neurodegenerative diseases.
Contents
1. Pathology, postmortem studies, neuromelanin
2. PD epidemiology and PD economic burden
3. Genetic influences and other causes
4. Animal models for the study of PD etiology
5. New cellular and organoid models for the study of PD
6. Lewy bodies, Molecular Interactions of Lewy bodies in the brain
7. Synaptophaty in PD; alpha-syn and tau relationship with PD
8. Parkinson's disease as a synucleinopathy
9. Lysosomal function and protein aggregation in PD
10. Autophagy and mitophagy and neuropathological markers of familiar PD
11. Mitochondrial dysfunction in PD
12. The gut brain axis in PD
13. Dopaminergic neurons susceptibility to degeneration / dysfunction of mitochondria, new PD models
14. Neuroinflammation and microglia
15. Extracellular space modifications and PD
16. Dopamine neurotransmission in Parkinson's Disease
17. Dopamine effects in striatal and subthalamic nucleus neurons
18. Adaptations that follow partial and severe striatal dopaminergic denervation
19. Molecular mechanisms underlying L-DOPA-induced dyskinesia, role of dopamine receptors
20. Imaging and electrophysiology of direct and indirect pathway neurons in freely moving animals
21. Striatal cholinergic system in PD
22. Striatal serotoninergic system in PD
23. Opto and chemogenetic studies on L-DOPA-induced dyskinesia
24. Network dynamics in rodent PD and LID models
25. Network dynamics in primate models and patients ; effects of DBS on network dynamics
26. Mechanisms underlying impulse control disorders in PD
27. Brain stem mechanism of PD symptoms
