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Gammadelta T cells in Cancer Immunotherapy shows how the potential of ?d T-cells can effectively be translated into clinical benefit in cancer immunotherapies. With a strong focus on finding alternatives to current T cell mediated cancer immunotherapies, the book can also be used as a baseline initial introduction to the field of gamma delta immunotherapy. In 13 chapters Gammadelta T cells in cancer immunotherapy describes different approaches to a specific model of gammadelta immunotherapy including 'delta one T' (DOT) and Allogeneic CAR. It describes the rationale for the use of gamma delta cells in immunotherapy, strategies, therapies, and cancer treatment.
Gammadelta T cells in Cancer Immunotherapy answers the growing interest in the scientific and medical community in general immunotherapy and familiarizes end users with the basic biology of gammadelta T cells, the pre-clinical studies implying their utility in immunotherapy, and with the studies of clinical applications of different forms of gammadelta T cell immunotherapeutic. modalities. Contents will help both basic scientists and clinicians understand how to overcome hurdles inherent to current forms of CAR T cell immunotherapy
Contents
Chapter 1 The rationale for use of gd T cells in immunotherapy.
Chapter 2 Tissue derived gammadelta T cells as vehicles for cancer immunotherapy
Chapter 3 DOT-1 gammadelta T cell immunotherapeutic strategies. 4
Chapter 4 Allogeneic Vg9Vd2 T cells treatment for solid tumors.
Chapter 5 Gammadelta T cell receptor therapeutic reagents; mechanisms and applications
Chapter 6 Immunotherapy based on bispecific antibodies targeting Vg9+ gd TCR and tumor antigens.
Chapter 7 . Intratumoral Allogeneic gammadelta T cell therapy for glioblastoma multiforme
Chapter 8 Allogeneic CAR expressing Vd1+ gammadelta T cells for lymphoma and hepatocellular carcinoma
Chapter 9 Activating Monoclonal antibodies directed against butyrophilin ligands of Vg9Vd2+ gammadelta T cells for cancer immunotherapy
Chapter 10 Pro tumoral gammadelta T cells and their implication for immunotherapy.
Chapter 11 Overcoming hurdles of gammadelta T cell immunotherapeutics
Chapter 12 Increasing efficacy of gammadelta immunotherapy by targeted modulation of tumor phosphoantigens.
Chapter 13 Summary and conclusions
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