Targeted Protein Degradation Technologies

個数：

Targeted Protein Degradation Technologies

Qin, Jiangjiang (EDT)/ Luan, Xin (EDT)/ Zhang, Weidong (EDT)

ウェブストア価格 ¥34,382（本体¥31,257）
Academic Press Inc（2025/07発売）
外貨定価 US$ 165.00
ポイント 312pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 402 p.
言語 ENG
商品コード 9780443218163
DDC分類 572.6

Full Description

Targeted Protein Degradation Technologies offers a comprehensive exploration of the field of targeted protein degradation, from its latest scientific advancements to its potential therapeutic applications. This book begins with a foundational introduction to the mechanisms of protein degradation, followed by an in-depth look at both protease-mediated and lysosome-mediated degradation pathways. The text delves into a range of cutting-edge technologies, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC, and AUTAC. It then explores the development of degraders for specific proteins, such as signal transduction receptors, membrane proteins, and transcription factors. This book concludes with a focused discussion on the clinical applications of targeted protein degradation and provides an insight into the future directions for this field.

This book serves as an invaluable resource for researchers and professionals in molecular biology, cell biology, and related disciplines, particularly those involved in protein degradation and the development of novel therapeutic strategies.

Part 1: Introduction
1. Mechanisms of protein degradation
2. Overview of targeted protein degradation

Part 2: Summary of targeted protein degradation
3. Protease-mediate degradation
4. PROTAC
5. AbTAC
6.  Molecular glues
7.  Hydrophobic tagging technology
8. Lysosome-mediate degradation
9. LYTACs
10.  Bispecific Apt amer Chimera (BIAC)
11.  GlueTAC
12. AUTACs
13. ATTECs
14. AUTOTAC

Part 3:  Degradation of Proteins of Interest
15. Degraders of signal transduction receptors
16. Degraders of membrane-associated proteins
17. Degraders of cell cycle- and anti-apoptosis-related proteins
18.  Degraders of proteins in epigenetic regulation
19. Degraders of proteins involved in transcription nuclear hormone receptors
20. Transcription factor degraders

Part 4: Clinical applications of targeted protein degradation
21. Clinical development of protein degraders