Full Description
Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of COVID-19 aims to cover all aspects of COVID-19 infection from the virus, transmission, pathogenesis, immune-inflammation response, systemic injury, organ damage, associated factors, and comorbidities that drive mortality. Organized into ten sections, the book aims to provide a comprehensive examination of the impact of COVID-19. The book begins a review of coronaviruses, their structure and mechanism of action. The book goes on to discuss the immune response to the virus and its effect on various organs. It examines clinical cases based on an observations and postmortem studies.
Other topics include the long-term effects of COVD-19, vaccines, and public health response.
Contents
Section 1: Coronaviruses (including SARS 1 and MERS), the Structure (sequence), Mechanism of Action
Introduction
1. Origin, Evolution and Spread of SARS-CoV-2
2. SARS-CoV-2 Spike Proteins in Infectivity
3. Structural and functional properties of the SARS-CoV-2 spike protein: potential vaccine and drug development for COVID-19
4. Population-Specific Polymorphisms and SARS-CoV-2 Infectivity
5. Insights into SARS-CoV-2 Structure: Approaches and Action of SARS-CoV-2 Main Protease Inhibitors
6. SARS-CoV-2, SARS-CoV, and MERS-COV: Similarities and Differences in Origin and Transmission
Section 2: Inflammation and Immune Response to SARS-CoV-2
Introduction
7. Characterization of the Immune Response with Viral Attack
8. Inflammation, Cytokines and COVID-19 Severity
9. Immunological Considerations for COVID-19: Vaccines and Other Protective Strategies
10. Virus-specific T cell response in SARS-CoV-2 infection and vaccinations
11. Oral and Gut Inflammation and Microbiota with COVID-19
12. Implications of Inflammation: Bone and Joint Health with COVID-19
13. COVID-19 and immune dysfunction: Consequences, and natural remedies for management
Section 3: Pathological Findings with Clinical Correlation
Introduction
14. Pulmonary Pathology of Severe Covid-19
15. Histopathological Analysis of the Cardiovascular System in severe COVID-19
16. Postmortem Neuropathology in COVID-19
17. Renal Pathology in Severe Covid-19
Section 4: The Blood Vessels and COVID-19: Vascular Dysfunction and Coagulopathies
Introduction
18. Vascular Manifestations of COVID-19: Endothelial Dysfunction and Damage
19. Immunothrombosis involvement in COVID-19
20. COVID-19 associated coagulopathy
21. D-dimer in systemic circulation and COVID-19 outcome
22. Hypercoagulability in COVID-19
Section 5: Neuro-COVID-19 and its Long-Term Implications
Introduction
23. COVID and the Nervous System: Mechanisms and Consequences
24. Neuroinflammation: Unraveling Acute and Long COVID-19 Effects
25. Acute and Post-acute Neurologic and Psychiatric Manifestations in COVID-19
26. Pediatric Neurological and Neuropsychiatric Manifestations of COVID-19
27. Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of Covid-19
Section 6: Should Covid-19 Concern Nephrologists? Why and to What Extent?"
Introduction
28. Acute Kidney Injury with COvid-19: Mechanisms, Management, and Long-term Outcomes
29. Models and Cellular Monolayers to Study the Effect of SARS-CoV-2 on Kidneys
30. Clinical implications of COVID-19 in chronic kidney disease and end-stage kidney disease
Section 7: Long COVID-19 (long term effects - summarizing of clinical reports in literature)
Introduction
31. Long COVID or Post-Acute Sequalae of COVID: An introduction
32. Long COVID: Pathophysiology and classification
33. Gender differences in Sequelae from COVID-19 Infection
34. Characterizing Long COVID-19: Lessons in the Clinic.
35. Implications of Long COVID for the Global Health Care System
Section 8: The Vaccines
Introduction
36. COVID-19: The Vaccine Development Strategies
37. mRNA vaccines: The New Frontier
38. Covid-19 vaccines: A Comprehensive review of Safety and Efficacy
Section 9: Handling the Spread: Public Health and Social Measures
Introduction
39. Lockdown measures during the COVID-19 pandemic
40. Efficacy of Facial masks against COVID-19
41. Vaccination Policies
42. Navigating the Impact of COVID-19 School Closures on Child Health, Education, and Society: A Call to Embrace Civil Discourse Across Identities, Sectors, and Disciplines
43. The Effect of the Pandemic on Care for Other Health Conditions
44. The role of smartphone-assisted tools for Covid-19 diagnostic, treatment, and quarantine
Section 10: From the Editors' desk
45. What have we learnt from the COVID-19 pandemic?
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