Full Description
Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body.
Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.
Contents
1. Biomarkers: Revolutionizing disease monitoring and therapeutic strategies
Anand More, Simranjit Kaur, Sakshi Bhatele, Nupur Vasdev, Tanisha Gupta, Bhakti Pawar and Rakesh Kumar Tekade
2. Connecting biotransformation with toxicity
Simranjit Kaur, Muktika Tekade, Bhakti Pawar, Nupur Vasdev, Tanisha Gupta, Nagaraja Sreeharsha and Rakesh Kumar Tekade
3. Idiosyncratic drug reactions and toxicities
Tanisha Gupta, Yogesh Wankhede, Muktika Tekade, Amrita Singh, Nupur Vasdev, Bhakti Pawar, Manoj Kumar and Rakesh Kumar Tekade
4. Importance of dose selection in toxicity studies
Mamata Panchal, Simranjit Kaur, Bhakti Pawar, Tanisha Gupta, Nupur Vasdev, Muktika Tekade and Rakesh Kumar Tekade
5. Implication of sex differences in toxicology
Anand More, Simranjit Kaur, Muktika Tekade, Vipulata Yeole, Prashant L. Pingale, Dattatraya Shinkar and Rakesh Kumar Tekade
6. Toxicological risk assessment and risk management
Suresh Shinde, Simranjit Kaur, Muktika Tekade, Bhakti Pawar, Tanisha Gupta, Nupur Vasdev, Basel Arafat and Rakesh Kumar Tekade
7. Adverse outcome pathway: A paradigm shift in chemical toxicological analysis
Sakshi Bhatele, Mahi Mhatre, Muktika Tekade, Nupur Vasdev, Bhakti Pawar and Rakesh Kumar Tekade
8. Design of toxicokinetic studies
Simranjit Kaur, Muktika Tekade, Nupur Vasdev, Bhakti Pawar, Tanisha Gupta, Aprameya Ganesh Prasad and Rakesh Kumar Tekade
9. Use of toxicokinetic data in preclinical safety assessment
Simranjit Kaur, Muktika Tekade, Nupur Vasdev, Bhakti Pawar, Shubham Mule, Girish Meravanige Basavarajappa and Rakesh Kumar Tekade
10. Drug-induced cardiotoxicity
Vinayak Pawar, Yogesh Wankhede, Simranjit Kaur, Bhakti Pawar, Nupur Vasdev, Tanisha Gupta, Pinaki Sengupta and Rakesh Kumar Tekade
11. Drug-induced immunotoxicity
Mahi Mhatre, Suresh Shinde, Simranjit Kaur, Nupur Vasdev, Muktika Tekade, Bhakti Pawar, Adil Ali Sayyed and Rakesh Kumar Tekade
12. Drug-induced photosensitivity
Bhakti Pawar, Yogesh Wankhede, Gurpreet Banth, Muktika Tekade, Tanisha Gupta, Richa Dayaramani and Rakesh Kumar Tekade
13. Toxic effects of cancer therapies
Shweta Ingole, Nupur Vasdev, Muktika Tekade, Tanisha Gupta, Bhakti Pawar, Mahi Mhatre, Aprameya Ganesh Prasad and Rakesh Kumar Tekade
14. High content screening in toxicology
Mamata Panchal, Bhakti Pawar, Muktika Tekade, Nupur Vasdev, Tanisha Gupta, Piyush Gondaliya and Rakesh Kumar Tekade
15. High-throughput screening in toxicity assessment
Kuldeep Rajpoot, Mamata Panchal, Bhakti Pawar, Nupur Vasdev, Tanisha Gupta, Muktika Tekade, Manish Sharma and Rakesh Kumar Tekade
16. Population pharmacokinetics/toxicokinetics
Kuldeep Rajpoot, Muktika Tekade, Bhakti Pawar, Pinaki Sengupta and Rakesh Kumar Tekade
17. Quantitative extrapolation interspecies scaling/low-dose extrapolation
Shivam Otavi, Tanisha Gupta, Muktika Tekade, Amrita Singh, Pinaki Sengupta, Ashish Agrawal and Rakesh Kumar Tekade
18. Toxicity and toxicodynamics of cryoprotectant used in pharmaceutical products
Prashant L. Pingale, Amarjitsing P. Rajput, Yash S. Chavan, Rupali A. Patil, Amrita Singh and Rakesh Kumar Tekade
19. Insect repellents as an environmental chemical toxicant to human health
Pratik Katare, Suryanarayana Polaka, Lakshmi Vineela Nalla, Vaishali Makwana and Rakesh Kumar Tekade
20. Clinical toxicity of antibodyedrug conjugates
Tanisha Gupta, Mamata Panchal, Vinayak Pawar, Muktika Tekade, Sanyam Gandhi and Rakesh Kumar Tekade
21. Cumulative toxicity of herbal drugs
Anand More, Shweta Ingole, Tanisha Gupta, Nupur Vasdev, Muktika Tekade, Randa SH. Mansour and Rakesh Kumar Tekade
22. Radiotherapy toxicity
Mamata Panchal, Shubham Mule, Yogesh Wankhede, Muktika Tekade, Tanisha Gupta, Aprameya Ganesh Prasad and Rakesh Kumar Tekade
23. Toxicities and toxicodynamic of anesthetics
Simranjit Kaur, Md Abubakar, Bhaskar Jyoti Dutta, Bhakti Pawar, Muktika Tekade, Prashant L. Pingale and Rakesh Kumar Tekade
24. Toxicity of nanomaterials
Anoothi Bain, Nupur Vasdev, Muktika Tekade, Dinesh Kumar Mishra, Pinaki Sengupta and Rakesh Kumar Tekade
25. Principles of management of acute poisoning
Mahi Mhatre, Simranjit Kaur, Muktika Tekade, Maliheh Safavi and Rakesh Kumar Tekade
26. Connecting link between pesticides and Parkinson's disease
Suryanarayana Polaka, Sivarupa Raji, Aditya Singh, Pratik Katare and Rakesh Kumar Tekade
27. Psychopharmacology in late life: Key challenges and opportunities
Shubham Mule, Vinayak Pawar, Muktika Tekade, Nupur Vasdev, Tanisha Gupta, Amrita Singh, Satyajit D. Sarker and Rakesh Kumar Tekade
28. Ethical, legal, societal, and professional issues in toxicology
Kuldeep Rajpoot, Shweta Ingole, Muktika Tekade, Bhakti Pawar, Tanisha Gupta, Pinaki Sengupta and Rakesh Kumar Tekade
