Regulatory T cells and Autoimmune Diseases

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Regulatory T cells and Autoimmune Diseases

Dwivedi, Mitesh Kumar (EDT)/ Fairweather, DeLisa (EDT)

ウェブストア価格 ¥52,096（本体¥47,360）
Academic Press Inc（2024/05発売）
外貨定価 US$ 250.00
ポイント 473pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 982 p.
言語 ENG
商品コード 9780443139475
DDC分類 616.0797

Full Description

Regulatory T Cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic applications. In particular, this book deals with various Treg-based mechanisms that can lead to autoimmune disease and covers different aspects linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.

This book specifically focuses on Treg-based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood and blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, this book covers vaccine-induced effects on the functioning of Tregs and development of CAR Treg therapy for autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. This book is carefully designed to meet the requirements of both basic and advanced researchers in the area and provide new dimensions and insight into regulatory T cells' role in autoimmune disease pathogenesis and therapy.

Part I Regulatory T cells and immune system
1. Regulatory T cells and their functions in immune system
2. Regulatory T cells: mechanisms of action
3. Regulatory T cells and autoimmunity
4. Sex differences in regulatory T cells during autoimmune disease

Part II Role of regulatory T cells in rheumatic diseases
5. Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus
6. Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren's syndrome
7. Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis
8. Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis
9. Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis
10. Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis

Part III Role of regulatory T cells in central nervous system demyelinating autoimmune diseases
11. Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis
12. Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder

Part IV Role of regulatory T cells in peripheral nerve, muscle and neuromuscular autoimmune diseases
13. Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis
14. Role of regulatory T cells in pathogenesis and therapeutics of GuillainBarré syndrome and experimental autoimmune neuritis
15. Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy
16. Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis

Part V Role of regulatory T cells in inflammatory bowel diseases
17. Role of regulatory T cells in pathogenesis and therapeutics of Crohn's disease and ulcerative colitis
18. Role of regulatory T cells in pathogenesis and therapeutics of celiac disease

Part VI Role of regulatory T cells in autoimmune liver diseases
19. Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis
20. Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis

Part VII Role of regulatory T cells in autoimmune thyroid diseases
21. Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto's thyroiditis
22. Role of regulatory T cells in pathogenesis and therapeutics of Graves' disease and Graves' orbitopathy

Part VIII Role of regulatory T cells in autoimmune lung and kidney diseases
23. Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture's syndrome (anti-glomerular basement membrane disease)
24. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy)

Part IX Role of regulatory T cells in autoimmune skin diseases
25. Role of regulatory T cells in pathogenesis and therapeutics of vitiligo
26. Role of regulatory T cells in pathogenesis and therapeutics of psoriasis
27. Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis
28. Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata
29. Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid
30. Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis)

Part X Role of regulatory T cells in autoimmune blood and blood vessel disorders
31. Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome)
32. Role of regulatory T cells in pathogenesis and therapeutics of Kawasaki disease
33. Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease
34. Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia
35. Role of regulatory T cells in pathogenesis and treatment of antineutrophil cytoplasmic antibody-associated vasculitis
36. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune hemolytic anemia

Part XI Role of regulatory T cells in autoimmune eye diseases and type 1 diabetes mellitus
37. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune uveitis
38. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune retinopathy
39. Role of regulatory T cell in pathogenesis and therapeutics of type 1 diabetes mellitus

Part XII Current challenges and future prospects in research towards regulatory T cells based therapeutics in autoimmune diseases
40. Vaccines induced effects on functioning of regulatory T cells: autoimmune perspective
41. Probiotic interventions for regulatory T cells' induction in autoimmune diseases
42. CAR Treg-based therapeutics for autoimmune diseases
43. Current challenges and future prospects of regulatory T cells based therapeutics in autoimmune disease