Full Description
This text covers all aspects of the study of adrenal cancer and the treatment of patients with the disease. Topics include epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, new developments in tumor profiling, and more.
Contents
Preface 1. History of ACC Research and Clinical Care 1.1. ACC - A 50 year retrospective view 1.2. History of ACC Treatment - A Surgical Perspective 2. Epidemiology, Presentation and Diagnosis 2.1. Epidemiology 2.2. Presentation and Diagnosis 2.3. Approach to the Adrenal incidentaloma 3.0. Imaging 3.1. Anatomic imaging 3.2. Functional imaging 4. Pathology 4.1. ACC Histopathology 4.2. Molecular and Cellular Pathology 5. Genetic & Molecular Aspects of ACC 5.1. Overview of the Genetics of ACC 5.2. Li Fraumeni Syndrome 5.3. P53 Molecular Genetics 5.4. Telomeres and ACC 5.5. Beckwith Wiedemann Syndrome 5.6. Insulin-like growth Factors 5.7. Wnt signaling 6. Models of Adrenocortical Cancer 6.1. Cellular origin and identity of ACC 6.2. Adrenocortical cell lines 6.3. Mouse Models of Adrenal Tumorigenesis 7. Therapies 7.1. Introduction 7.2. Mitotane 7.3. Cytotoxic Chemotherapy 7.4. Steroidogenesis and Therapy of Hormone Excess 7.5. Surgical therapy 7.6. Radiation Therapy 7.7. Surveillance and follow up of ACC 8 Unique ACC Cohorts and Future Perspectives 8.1.. Aldosterone producing ACC 8.2. Childhood ACC 8.3. Molecular Profiling of Adrenal Cancer 8.4. Clinical Registries: Dutch and European experiences 8.5. Emerging Strategies
