Full Description
We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists.
We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.
Contents
Preface 1. History of ACC Research and Clinical Care 1.1. ACC - A 50 year retrospective view 1.2. History of ACC Treatment - A Surgical Perspective 2. Epidemiology, Presentation and Diagnosis 2.1. Epidemiology 2.2. Presentation and Diagnosis 2.3. Approach to the Adrenal incidentaloma 3.0. Imaging 3.1. Anatomic imaging 3.2. Functional imaging 4. Pathology 4.1. ACC Histopathology 4.2. Molecular and Cellular Pathology 5. Genetic & Molecular Aspects of ACC 5.1. Overview of the Genetics of ACC 5.2. Li Fraumeni Syndrome 5.3. P53 Molecular Genetics 5.4. Telomeres and ACC 5.5. Beckwith Wiedemann Syndrome 5.6. Insulin-like growth Factors 5.7. Wnt signaling 6. Models of Adrenocortical Cancer 6.1. Cellular origin and identity of ACC 6.2. Adrenocortical cell lines 6.3. Mouse Models of Adrenal Tumorigenesis 7. Therapies 7.1. Introduction 7.2. Mitotane 7.3. Cytotoxic Chemotherapy 7.4. Steroidogenesis and Therapy of Hormone Excess 7.5. Surgical therapy 7.6. Radiation Therapy 7.7. Surveillance and follow up of ACC 8 Unique ACC Cohorts and Future Perspectives 8.1.. Aldosterone producing ACC 8.2. Childhood ACC 8.3. Molecular Profiling of Adrenal Cancer 8.4. Clinical Registries: Dutch and European experiences 8.5. Emerging Strategies
