腫瘍免疫抑制 Tumor Induced Immune Suppression : Mechanisms and Therapeutic Reversal

Gabrilovich, D. I. (EDT)/ Andy, H. (EDT)

Springer（2008/01発売）

• 製本 Hardcover:ハードカバー版／ページ数 575 p.／サイズ 50 illus.
• 商品コード 9780387691176

基本説明

Discusses a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance.

Full Description

This monograph, for the first time, presents a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It discusses a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance. There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in a more or less cohesive structure and how they can help to improve immune response to tumors.

Contents

Immune-Suppressive Mechanisms and CancerImplications, Paradoxes, and Burning Questions.- Mechanisms of Tumor-Associated T-Cell Tolerance.- Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer.- Regulatory T Cells in Cancer.- Cancer-Induced Signaling Defects in Antitumor T Cells.- Immunobiology of Dendritic Cells in Cancer.- Macrophages and Tumor Development.- Myeloid-Derived Suppressor Cells in Cancer.- Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance.- Arginine Availability Regulates T-Cell Function in Cancer.- Protein-Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3.- Role of Reactive Oxygen Species in T-Cell Defects in Cancer.- Tumor Stroma and the Antitumor Immune Response.