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Full Description
This book introduces basic pharmacokinetic concepts to beginner learners to help them understand the absorption, distribution, metabolism, and excretion of drugs.
After a basic introduction to pharmacokinetics and its related fields, the book provides a clear introduction to quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters after different routes of drug administration. Emphasizing the application and importance of pharmacokinetic concepts in clinical practice throughout, the book features:
A clear, simple, and concise style with the use of graphs and simulations to aid learning.
Bullet point summaries of each concept to demonstrate applications in clinical practice.
Practice problems and solved examples to help the reader understand the best approach for calculating pharmacokinetic parameters.
A glossary of key words and acronyms.
This book is an essential read for undergraduate and graduate pharmacokinetic students in pharmacy, pharmacology, and pharmaceutical science programs worldwide.
Accompanying the book is a website with self-instructional tutorials and pharmacokinetic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this textbook.
Contents
1.Introduction to Pharmacokinetics. 2.Drug Pharmacokinetics Following Single Intravenous Bolus Administration: Drug Distribution. 3.Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Clearance. 4.Drug Pharmacokinetics Following Single IV Bolus Administration: The Rate of Drug Elimination. 5.Drug Absorption Following Extravascular Administration: Biological, Physicochemical, and Formulation Considerations. 6.Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption. 7.Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption. 8.Bioequivalence. 9.Drug Pharmacokinetics during Constant Rate IV Infusion, the Steady State concept. 10.Steady State during Multiple Drug Administration. 11.Renal Drug Excretion. 12.Metabolite Pharmacokinetics. 13.Nonlinear Pharmacokinetics. 14.Multicompartment Pharmacokinetic Models. 15.Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusions. 16.Physiological Approach to Hepatic Clearance. 17.Pharmacokinetics in Patients with Eliminating Organ Dysfunction. 18.Noncompartmental Approach in Pharmacokinetic Data Analysis. 19.Pharmacokinetic-Pharmacodynamic Modeling. 20.Pharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability. 21.Therapeutic Drug Monitoring. 22.Pharmacometic Applications in Drug Development and Individualization of Drug Therapy. 23.Answer to Practice Problems.
