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Full Description
To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emitters to receptors. Thus, these channels are strategically situated in the thin line between life and death, guaranteeing adequate but safe signaling.
Key Features:
- Provides a brief history of the discovery and characterization of peroxiporins
- Reviews key findings on hydrogen peroxide transport across biological membranes
- Discusses the cartography of redox signaling in crowded cells
- Includes lavish illustrations and comprehensive images to facilitate teaching
- Highlights recent findings, outstanding controversies and open questions
Contents
Chapter 1-Role of the cellular hydrogen peroxide landscape profile in redox signaling
Helmut Sies
Chapter 2-How gradients and microdomains determine H2O2 redox signaling
Fernando Antunesa, Armindo Salvador
Chapter 3-Diffusion and transport of peroxynitrite across cell membranes
Matías N. Möllera, Karina Allevac, Ari Zeidab, Rafael Radib
Chapter 4-Hydrogen peroxide as a substrate for aquaporins from a structure-function perspective
Eric Beitz
Chapter 5-Use of genetically encoded reporters to quantify intracellular H2O2 levels in eukaryotic cells
Laura de Cubasa, Fernando Antunesb, Olga Lyublinskayac, and Elena Hidalgoa
Chapter 6-H2O2/ROS production, consumption and transport across organelles
Tasuku Konno, Cécile Crapart, Edward Avezov
Chapter 7-The Mystery behind Hydrogen Peroxide Permeation across the Peroxisomal Membrane
Cláudio F. Costaa, Celien Lismont, Marco Anteghini, Iulia Revenco, Hongli Li, Marc Fransen
Chapter 8-Role of mammalian aquaporin (AQP) inside the cell: An update.
Kenichi Ishibashi, Yoshiyuki Morishita, Yasuko Tanaka-Mochizuki
Chapter 9-Peroxiporins in plant-microbial interactions
Barbara Ludwig Navarro, Kathrin Blumenstein, Daniela Elisabeth Nordzieke
Chapter 10-Role of peroxiporins in plant stress signaling and development
Stephanie Frohn, Bernd Dreyer, Romy Schmidt-Schippers, Jos H.M. Schippers
Chapter 11-Evolution and function of peroxiporins in piscine spermatozoa
Joan Cerdà, François Chauvigné, Roderick Nigel Finn
Chapter 12-Regulated Transport of H2O2 Across the Plasma Membrane by Aquaporin-8
Milena Bertolotti, José Manuel García-Manteiga, Roberto Sitia
Chapter 13- Peroxiporins as crucial advocates of redox architecture
Ilaria Sorrentino, Angie K. Molina-Oviedo, Eduardo Arevalo-Nuñez de Arenas, Iria Medraño-Fernandez
Chapter 14- The history on the discovery of peroxiporins
Tobias Henzler, Michael Broberg Palmgren and Gerd Patrick Bienert
