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Full Description
The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms.
Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.
Key Features:
Reviews how extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients
Focuses on equipment and process technology
Explains various extrusion system configurations as a manufacturing methodology for a variety of dosage forms
Presents new opportunities available only via extrusion and future trends
Includes contributions of experts from the process and equipment fields
Contents
Chapter 1: Twin Screw Extruders for Pharmaceutical Products from a Technical and Historical Perspective. Chapter 2: Extruder Design. Chapter 3: Control Strategy Considerations for Continuous Manufacturing using Hot Melt Extrusion. Chapter 4: Twin Screw Extrusion & Screw Design. Chapter 5: Die Design. Chapter 6: Feeding Technology and Material Handling for Pharmaceutical Extrusion. Chapter 7: Rheology, Torque and Oscillatory Rheometers. Chapter 8: Foam Extrusion. Chapter 9: Melt Pelletization and Size Reduction. Chapter 10: Extended Release Dosage Forms. Chapter 11: Shape Extrusion - Extruded Implantable Drug Delivery Devices: Materials, Applications and Processing. Chapter 12: Film, Sheet and Laminates. Chapter 13: Melt Extruded Amorphous Solid Dispersions. Chapter 14: Process Modeling and Simulation of Extrusion Operations. Chapter 15: Devolatilization via Twin Screw Extrusion: Theory, Tips, and Test Results. Chapter 16: Continuous Granulation Methodologies. Chapter 17: Installation, Commissioning & Qualification. Chapter 18: Extruder Control Systems.
