Full Description
Pain is a serious health problem. This book presents an intensive review of the anatomy, physiology, and pharmacology of the systems that mediate nociceptive processing. The authors cover areas that include anatomy, central and peripheral nerve processing, tissue and nerve injury states, as well as preclinical and clinical models of pain. Mechanisms of Pain also covers important clinical concepts, with specific emphasis on mechanisms of action. Written by world renowned global faculty, this book covers important areas of science required to understand pain medicine. Important topics covered include post-tissue and nerve injury pain states of primary afferents and the spinal cord. The authors also cover mechanisms of action of clinically relevant analgesics (opiates and non-opiates), psychological aspects of pain, pathophysiology of migraines, as well as the genetics of pain. This comprehensive book is to guide undergraduate, graduate, and clinicians in the field of pain medicine on important concepts related to the science and practice of pain.
Contents
Chapter 1- Introductory and Key Concepts in the Basis of Pain
Chapter 2- Organization of the Nervous System: Gross Anatomy
Chapter 3- Neurophysiology of Pain - Peripheral
Chapter 4- DRG/Peripheral Nerve: Multicellular Modality and Coding
Chapter 5- Peripheral Nerve and Dorsal Root Ganglion (DRG) Pharmacology: Mechanisms, Therapeutic Targets, and Clinical Applications
Chapter 6- Dorsal Horn Organization and Processing
Chapter 7- The Psychophysiology of Pain
Chapter 8- Post Tissue Injury Pain State - Primary Afferent
Chapter 9- Post Tissue Injury Pain State - Spinal Cord
Chapter 10- Post Nerve Injury Pain States (Primary Afferent)
Chapter 11- Spinal Cord
Chapter 12- Visceral Pain System/ Neuro-Immune Interaction
Chapter 13- Preclinical Models of Pain
Chapter 14- Human Experimental Pain Models: Clinical Applications and Molecular Mechanisms in Drug Development
Chapter 15- Psychological Aspects of Pain: A Focus on Depression
Chapter 16- Neuromodulation
Chapter 17- Mechanisms of Action of Clinically Relevant Analgesics (Opioids)
Chapter 18- Mechanisms of Action of Clinically Relevant Analgesics (Non-Opiates)
Chapter 19- "Pathophysiology of Migraine"
Chapter 20- Genetics of Pain
Chapter 21- Chronic Low Back Pain: Etiology and Treatment
