Full Description
Over the past few decades, there has been an exponential growth of interest in the field of toxicologic pathology, a critical field in safety science, particularly as related to its impact on nonclinical safety in global drug development and care of the environment. Photomicrographic examples of selected nonproliferative and proliferative lesions are necessary to complement the written narratives in textbooks on toxicologic pathology. Toxicologic Pathology: An Atlas fits that need with input provided by top experts in the field. It will become a valuable reference, not only for toxicologic pathologists, but also for a wide variety of nonclinical safety scientists, especially in the pharmaceutical and biotech industries.
This book provides illustrations and descriptions of commonly observed findings in toxicologic pathology (i.e., over 1100 photomicrographic examples). These illustrations add visual context to the terms and descriptions commonly used in the field. The illustrations and accompanying descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development. The Atlas is designed to be practical, easy to use and written with the hope that it will become a reliable "go-to" reference that will be of interest to students and nonscientists (e.g., individuals serving on animal care and use committees) as a key, single source to understanding terminology and visualizing tissue changes described by toxicologic pathologists.
Contents
Biographies
List of Contributors
Preface
Acknowledgments
Chapter 1 Introduction to Toxicologic Pathology
Xavier Palazzi, Xiantang Li, K. Nasir Khan, and John Burkhardt
Chapter 2 Musculoskeletal System and Teeth
Agathe Bedard, Kathryn E. Gropp, Ryan M. Schafbuch, and John L. Vahle
Chapter 3 Cardiovascular System
Vasudevan Bakthavatchalu, Vasanthi Mowat, and Bindu Bennet
Chapter 4 Endocrine System
Richard Lang, Thomas J. Rosol, George Schaaf, Priyanka Thakur, and Haoan Wang
Chapter 5 Digestive Tract
Allison Boone, Judit Markovits, Elizabeth McInnes, Thomas Nolte, and Arun Pandiri
Chapter 6 Hematopoietic System
Florence Poitout-Belissent, Pini Zvionow, Mark Smith, and Johannes Harleman
Chapter 7 Integumentary System
Rie Kikkawa, Nagaraja Muniappa, and Maurice Cary
Chapter 8 Liver, Gallbladder, and Exocrine Pancreas
Bob Thoolen, Shekar Chelur, and Robert R. Maronpot
Chapter 9 Lymphoid System
Erin M. Quist, Richard Lang, and Haoan Wang
Chapter 10 The Nervous System
Debra A. Tokarz, Peter B. Little, and Robert C. Sills
Chapter 11 Female Reproductive System
Daniel Rudmann
Chapter 12 Male Reproductive System and Mammary Gland
Alexandra D. Rogers, Justin D. Vidal, and Catherine Picut
Chapter 13 Respiratory System
Jerry F. Hardisty, Zbigniew W. Wojcinski, Torrie Crabbs, Ron Herbert, Chunyan Hu, and Ke Chen
Chapter 14 Special Senses
JoAnn C. L. Schuh, Jean-Francois Lafond, Typhaine Lejeune, and Steven D. Sorden
Chapter 15 Urinary System
Gordon C. Hard, Samuel M. Cohen, and John Curtis Seely
Chapter 16 Artifacts in Toxicologic Pathology
Thomas J. Steinbach and Shuang Qiu
Chapter 17 Tg.rasH2 Mouse Model
Aaron Sargeant, Rossalin Y. Cutts, and Timothy Carlson
Index
