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Full Description
Over the past few decades, there has been an exponential growth of interest in the field of toxicologic pathology, a critical field in safety science, particularly as related to its impact on nonclinical safety in global drug development and care of the environment. Photomicrographic examples of selected nonproliferative and proliferative lesions are necessary to complement the written narratives in textbooks on toxicologic pathology. Toxicologic Pathology: An Atlas fits that need with input provided by top experts in the field. It will become a valuable reference, not only for toxicologic pathologists, but also for a wide variety of nonclinical safety scientists, especially in the pharmaceutical and biotech industries.
This book provides illustrations and descriptions of commonly observed findings in toxicologic pathology (i.e., over 1100 photomicrographic examples). These illustrations add visual context to the terms and descriptions commonly used in the field. The illustrations and accompanying descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development. The Atlas is designed to be practical and easy to use and written with the intent that it would become a reliable "go-to" reference, and will be of interest to students and nonscientists (i.e., individuals serving on animal care and use committees) as a key, single source reference to understanding terminology and visualizing tissue changes described by toxicologic pathologists.
Contents
1. Introduction to Toxicologic Pathology:
Xavier Palazzi, Xiantang Li, K. Nasir Khan, John Burkhardt
2. Musculoskeletal System and Teeth:
Agathe Bedard, Kathryn E. Gropp, Ryan M. Schafbuch, John L. Vahle
3. Cardiovascular System:
Vasu Bakthavatchalu, Vasanthi Mowat, Bindu Bennett
4. Endocrine System:
Richard Lang, Thomas Rosol, George Schaaf, Priyanka Thakur, Haoan Wang.
5. Digestive Tract:
Allison Boone, Judit Markovits, Elizabeth McInnes, Thomas Nolte, Arun Pandiri
6. Hematopoietic System:
Florence Poitout-Belissent, Pini Zvionow, Mark Smith, Johannes Harleman
7. Integumentary System:
Rie Kikkawa, Nagaraja Muniappa, Maurice Cary
8. Liver, Gallbladder, and Exocrine Pancreas:
Bob Thoolen, Shekar Chelur, Robert R. Maronpot
9. Lymphoid System:
Erin M. Quist, Richard Lang, Haoan Wang
10. The Nervous System:
Debra A. Tokarz, Peter B. Little, Robert C. Sills
11. Female Reproductive System:
Daniel Rudmann
12. Male Reproductive System and Mammary Gland:
Alexandra D. Rogers, Justin D. Vidal, Catherine Picut
13. Respiratory System:
Jerry Hardisty, Zbigniew W. Wojcinski, Torrie Crabbs, Ron Herbert, Chunyan Hu, Ke Chen
14. Special Senses:
Joann C. L. Schuh, Jean-Francois Lafond, Typhanie Lejeune, Steven D. Sorden
15. Urinary System:
Gordon C. Hard, Samuel M. Cohen, John Curtis Seely
16. Artifacts in Toxicologic Pathology:
Thomas J. Steinbach, Shuang Qiu
17. Tg.rasH2 Mouse Model:
Aaron Sargeant, Rossalin Y. Cutts, Timothy Carlson