Full Description
Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies.
Contents
Introduction o Progressive Development of the Viral Therapy of Human Cancers: A Personal Narrative Account Joseph G. Sinkovics o New Biological Therapeutics: Competitors or Collaborators in Viral Therapy for Human Cancers Joseph G. Sinkovics o Naturally Oncolytic Viruses o Measles Virus: Improving Natural Oncolytic Properties by Genetic Engineering Christoph Springfield, Adele Fielding, Kah-Whye Peng, Eva Galanis, Stephen J. Russell, and Roberto Cattaneo o Newcastle Disease Virus: Anti-tumor Immune Memory and Its Activation for Control of Residual Tumor Cells and Improvement of Patient Survival Volker Schirrmacher o Newcastle Disease Virus: Its Oncolytic Properties Joseph C. Horvath o Influenza A Viruses with Deletions in the NS1 Gene: A Rational Approach to Develop Oncolytic Viruses Michael Bergmann and Thomas Muster o Vesicular Stomatitis Virus: An Oncolytic Agent Rebecca A. C. Taylor, Jennifer M. Paterson, and John C. Bell o Parvoviruses as Anti-Cancer Agents Jean Rommelaere, Nathalia Giese, Celina Cziepluch, and Jan J. Cornelis o Viral Oncolysates o Newcastle Disease Virus Oncolysate in the Management of Stage III (AJCC) Malignant Melanoma William A. Cassel, Douglas R. Murray, and Zbigniew L. Olkowski o Vaccinia Viral Lysates in Immunotherapy of Melanoma Peter Hersey o Genetically Engineered Oncolytic Viruses o Fusogenic Oncolytic Herpes Simplex Viruses for Therapy of Solid Tumors Xinping Fu, Mikihito Nakamori, and Xiaoliu Zhang o Poliovirus Recombinants Against Malignant Glioma Melinda Merrill, David Solecki, and Matthias Gromeier o Oncolytic Viruses that Depend on Loss of RB or p53 Frank McCormick
