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Full Description
Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and classification problems in two main high-throughput platforms: microarray gene expression and phylogenic analysis.
The book explores Bayesian techniques and models for detecting differentially expressed genes, classifying differential gene expression, and identifying biomarkers. It develops novel Bayesian nonparametric approaches for bioinformatics problems, measurement error and survival models for cDNA microarrays, a Bayesian hidden Markov modeling approach for CGH array data, Bayesian approaches for phylogenic analysis, sparsity priors for protein-protein interaction predictions, and Bayesian networks for gene expression data. The text also describes applications of mode-oriented stochastic search algorithms, in vitro to in vivo factor profiling, proportional hazards regression using Bayesian kernel machines, and QTL mapping.
Focusing on design, statistical inference, and data analysis from a Bayesian perspective, this volume explores statistical challenges in bioinformatics data analysis and modeling and offers solutions to these problems. It encourages readers to draw on the evolving technologies and promote statistical development in this area of bioinformatics.
Contents
Estimation and Testing in Time-Course Microarray Experiments, Classification for Differential Gene Expression Using Bayesian Hierarchical Models, Applications of the Mode Oriented Stochastic Search (MOSS) for Discrete Multi-Way Data to Genome -Wide Studies, Nonparametric Bayesian Bioinformatics, Measurement Error Models for cDNA Microarray and Time-to-Event Data with Applications to Breast Cancer, Robust Inference for Differential Gene Expression, Hidden Markov Modeling of Array CGH Data, Recent Developments in Bayesian Phylogenetics, Gene Selection for the Identification of Biomarkers in High-Throughput Data, Sparsity Priors for Protein-Protein Interaction Predictions, Learning Bayesian Networks for Gene Expression Data, In Vitro to In Vivo Factor Profiling in Expression Genomics, Proportional Hazards Regression Using Bayesian Kernel Machines, Mixture Model for Protein Biomarker Discovery, and Bandopadhyay Bayesian Methods for Detecting Differentially Expressed and Empirical Bayes Methods for Spotted Microarray Data Bayesian Classification Method for QTL Mapping
