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Full Description
First published in 1989, written with contributions from experts who have critically evaluated the state of the art and the prospects of isolated adults cardiac myocytes in cardiological research, this two-volume publication summarizes the current knowledge of this technology. The methodology, structure, and metabolism of cardiomyocytes are presented, along with metabolism and cation homeostasis and energy metabolism and hypoxic injury. Additionally, cell isolation and culture and the structure and biochemistry of the sarcolemma is explained. Electrophysiology and contractile function with ionic currents and membrane channels is discussed. Also, the electro-physiological effects of transmitters and hormones are presented, with excitation-contraction coupling and the use of cardiomyocytes in drug design and research explained.
Contents
Volume I.1. Constituent Cells of the Heart and Isolated Cell Models in Cardiovascular Research. 2. Techniques for Isolation and Culture of Adult Cardiomyocytes.CATION HOMEOSTASIS.3. Cation Homeostasis in Isolated Adult Cardiac Myocytes. 4. Homeostasis of Calcium Ions in Calcium-Tolerant Myocytes.5. Ultrastructure of the Sarcolemma of Isolated Cardiomyocytes. 6. Biochemistry of Sarcolemma of Isolated Cardiomyocytes. 7. Adrenergic, Cholinergic, and Other Hormone Receptors on Cardiac Myocytes.ENERGY METABOLISM.8. Oxygen Delivery and Oxidative Phosphorylation in Isolated Adult Ventricular Myocytes. 9. Metabolism of Purines by Adult Cardiomyocytes. 10. Substrate Metabolism of Isolated Cardiomyocytes.HYPOXIC CELL INJURY.11. Energy Metabolism and Hypoxic Injury of Cardiomyocytes. 12. Cytosolic Ca(2)+ in Hypoxic Cardiomyocytes. Index.Volume II.1. Constituent Cells of the Heart and Isolated Cell Models in Cardiovascular Research. 2. Techniques for Isolation and Culture of Adult Cardiomyocytes. CATION HOMEOSTASIS.3. Cation Homeostasis in Isolated Adult Cardiac Myocytes. 4. Homeostasis of Calcium Ions in Calcium-Tolerant Myocytes.5. Ultrastructure of the Sarcolemma of Isolated Cardiomyocytes. 6. Biochemistry of Sarcolemma of Isolated Cardiocytes. 7. Adrenergic, Cholinergic, and Other Hormone Receptors on Cardiac Myocytes.ENERGY METABOLISM.8. Oxygen Delivery and Oxidative Phosphorylation in Isolated Adult Ventricular Myocytes. 9. Metabolism of Purines by Adult Cardiomyocytes. 10. Substrate Metabolism of Isolated Cardiomyocytes. HYPOXIC CELL INJURY.11. Energy Metabolism and Hypoxic Injury of Cardiomyocytes. 12. Cytosolic Ca(2)+ in Hypoxic Cardiomyocytes. Index.
