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Full Description
This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols.
Key Features
Presents the first full guide to single-stranded RNA phages
Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences
Demonstrates how RNA phage-derived products have resulted in nanotechnological applications
Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
Contents
Introduction.
1. History and first look.
2. Taxonomy and grouping.
3. Pili hosts.
4. Physiology and growth.
5. Distribution.
6. Ecology.
7. Genome.
8. Genetics and mutants.
9. Particles.
10. RNA.
11. Maturation protein.
12. Coat protein.
13. Replicase.
14. Lysis protein.
15. Immunology.
16. Translation.
17. Replication.
18. Evolution.
19. Expression.
20. Chimeric VLPs.
21. 3D particles.
22. VLP vaccines.
23. Non-vaccine VLPs.
24. Non-VLPs.
25. Epilogue.
