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Full Description
Mechanisms of Morphogenesis, Third Edition offers a bottom-up discussion of mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. Across foundational, applied and methods-based chapters, this book examines molecular nano-machines cooperation, generate cell shape, direct cell migration, and shape, form and rates of growth of various tissues in the body. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and likely future developments, along with strategies to apply basic morphogenesis science across ever evolving applications.
Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues.
Contents
Section I: Introduction
1. General introduction - the aims and structure of this book.
2. Key principles of morphogenesis
3. The power and limitations of self-assembly
Section II: Cell shape and the cell morphogenesis
4. Morphogenesis of individual cells
5. Animal cell shape: the importance of the cytoskeleton
6. Cellular morphogenesis in plants
Section III: Cell Migration
7. Cell migration in development: a brief overview
8. The nanomachinery of locomotion
9. Guidance by chemotaxis
10. Guidance by galvanotaxis
11. Guidance by contact
12. Waypoint navigation in the embryo
13. Cooperative migration of mesenchymal cells
14. Condensation of cells
Section IV: Epithelial Morphogenesis
15. The epithelial state: a brief overview
16. Neighbour exchange and convergent extension
17. Closure of holes
18. Invagination and evagination
19. Epithelial fusion
20. Epithelial branching
21. Boundaries to epithelial movement
Section V: Morphogenesis by cell proliferation and death
22. Growth, proliferation and death: a brief overview
23. Morphogenesis by orientated cell division
24. Morphogenesis by elective cell death
Section VI: Morphogenesis in context
25. From mechanisms to morphology: a brief overview
26. Morphogenesis in embryos: some illustrative examples
27. Morphogenesis in organoids, embryoids and engineered tissues
28. Pathological morphogenesis
Section VII: Modelling morphogenesis
29. Modelling morphogenesis: a brief overview
30. Mechanical and mathematical models of morphogenesis
31. Modelling using living cells - tissue engineering and synthetic morphology
Section VIII: Conclusion and perspectives
32. Conclusion and perspectives
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