Full Description
Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices.
Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.
Contents
1. Basic principles and concept in Toxicokinetic
2. Factors Influencing Drug Toxicity
3. Molecular biology of apoptotic, necrotic and necroptotic cell death
4. Toxicogenomic in drug safety assessment
5. Understanding the concept of signal toxicity
6. Importance of toxicity testing
7. Methods and Models for in vitro toxicity
8. New Emerging technologies for genetic toxicity testing
9. Zebrafish models for toxicological screening
10. Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs
11. Food-Drug Interactions and their Implications on Oral Drug Bioavailability
12. Drug-Drug interactions and their implications on the Pharmacokinetics of the Drugs
13. Clinical Importance of Herb-Drug interaction
14. Insilico methods for the prediction of drug toxicity
15. Organ-on-a-chip for assessing environmental toxicants
16. Toxicity and toxicokinetics consideration in product development and drug research
17. Drug Toxicity and Forensic Pharmacokinetics
18. Excipient's toxicity and safety
19. Pharmaceutical excipients: Special focus on Adverse drug interactions
20. Emerging role of novel excipients in drug product development and their safety concerns
21. Toxicity of Pharmaceutical azo dyes
22. Environmental and Safety Aspects of Bionanotechnology
23. Toxicological Risk assessment of medical devices
24. Developmental toxicity of nanomaterials used in healthcare
25. Ethical defilements in clinical research and potential roles of Institutional review board
26. Toxicodynamic in Drug research
