Full Description
Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset.
With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.
Contents
I. Oxidative Stress and Disease
1. Oxidative stress causes
2. Historical perspective
3. Chemicals and chemical mixtures
4. Particles and fibers
5. Air pollution
6. Alcohol, tobacco and recreational drug use
7. Radiation
8. Chronic inflammation
9. Chronic Trauma
10. Dietary choices
11. Sleep deprivation
12. Hot and cold Environmental temperature extremes
13. Pre-existing disease
14. Pharmaceutical drugs
15. Chronic psychological stress
16. Genetic and epigenetic factors
II. Mechanism of Disease Onset
17. Disease hallmarks and biomarkers
18. Disease clusters
19. Disease co-morbidities
20. Free radical attack on DA
21. Free radical attack on proteins
22. Free radical attack on lipophilic cell membranes
23. Free radical stability factors
24. Free radical attack on mitochondria and energy production
25. Immune System role
26. Obesity-oxidative stress-disease triangle: Impact of obesity oxidative stress and disease
27. Acute versus chronic oxidative stress
28. Age and late onset disease
29. Total oxidative stress
III. Oxidative Stress Index and Its Applications
30. Oxidative stress index and its premise
31. Predicting likelihood of disease onset
32. Identifying primary causes of specific diseases
33. Oxidative Stress Index as a public health survey instrument
34. Adverse drug reaction prediction
35. Predicting severity of COVID-19 and other diseases
36. Oxidative Stress Index as a virtual diagnostic tool
37. Disease prevention
38. Future applications
