インフラマソーム生物学 Inflammasome Biology : Fundamentals, Role in Disease States, and Therapeutic Opportunities

Pelegrin, Pablo (EDT)

Academic Press Inc（2022/11発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 672 p.
• 言語 ENG
• 商品コード 9780323918022
• DDC分類 616.0473

Full Description

Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds.

This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.

Contents

Part I - Fundamentals of Inflammasome Biology
1. Overview of inflammatory processes at cellular level
2. Inflammasome formation and triggers
3. Cellular signaling, molecular activation and regulation of the NLRP1 inflammasome
4. Cellular signaling, molecular activation and regulation of the NLRP3 inflammasome
5. Cellular signaling, molecular activation and regulation of the NLRP6 inflammasome
6. Cellular signaling, molecular activation and regulation of the NLRC4 inflammasome
7. Cellular signaling, molecular activation and regulation of the AIM2 inflammasome
8. Cellular signaling, molecular activation and regulation of the Pyrin inflammasome
9. Cellular signaling, molecular activation and regulation of the non-canonical inflammasome
10. Cellular signaling, molecular activation and regulation of auto-active inflammasomes
11. Autophagy and the inflammasome
12. Inflammasome effector functions
13. Inflammatory caspases
14. Structural aspects of inflammasomes
15. Evolutive aspects of inflammasomes

Part II - inflammasome role in disease processes
16. The inflammasome in cardiovascular diseases
17. Inflammasome implications in metabolic disorders
18. Inflammasome in venous thromboembolic disorders
19. Inflammasomes and neurodegenerative diseases
20. Inflammasome implication in diseases of the respiratory system
21. Inflammasomes and their regulation in oral disease
22. Inflammasomes in inflammatory bowel disease pathogenesis
23. Inflammasome induced inflammation and fibrosis in liver
24. Inflammasomes in sepsis
25. The Inflammasome in viral, bacterial and fungal infections
26. Autoinflammatory syndromes
27. The inflammasome in graft-versus-host disease
28. Implication of the inflammasomes in rheumatic diseases
29. The inflammasomes in kidney disease
30. Inflammasomes and cancer
31. Inflammasomes in the pathobiology of degenerative retinopathies.

Part III - Inflammasome crosstalk in Cell Death
32. Regulation of pyroptosis by inflammasomes.
33. Crosstalk between necroptosis and inflammasome.
34. Apoptosis and inflammasome regulation
35. Implication of inflammasomes regulating different types of cell death
36. Regulation of neutrophil NETosis by inflammasomes

Part IV - Therapeutic Opportunities
37. Therapeutic opportunities targeting the inflammasome
38. Development of selective inflammasome Inhibitors
39. Natural compounds blocking inflammasomes
40. Inhibitors targeting inflammasome effectors
41. Multi-inflammasome inhibitors