ヒトの加齢の分子・神経・代謝生物学的基礎 Molecular, Cellular, and Metabolic Fundamentals of Human Aging

Fang, Evandro Fei/ Bergersen, Linda Hildegard/ Gilmour, Brian C.

Academic Press Inc（2022/10発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 260 p.
• 言語 ENG
• 商品コード 9780323916172
• DDC分類 612.67

Full Description

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion.

The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.

Contents

1. Decoding the mystery of ageing and the hallmarks of ageing

Section I. The Genome
2. Epigenetic ageing and its reversal

Section II. Metabolism, Homeostasis and Communication
3. Nutrient sensing and aging
4. Dysregulated proteostasis

Section III. Autophagy and Bioenergetics
5. Autophagy and bioenergetics in aging

Section IV. Senescence
6. Senescence in Ageing

Section V. Applications
7. Ageing and the immune system
8. Canonical and novel strategies to delay or reverse ageing