Full Description
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses
Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms
Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis
Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others
Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms
Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Contents
SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN
NORMAL HISTOLOGY
4 Introduction to Spleen
Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD
12 Imaging of Splenic Disorders
Mohammad A. Vasef, MD
18 Handling, Processing, and Gross Pathology of Spleen
26 Fine-Needle Aspiration and Core Biopsy of Spleen
32 Immunohistochemistry of Spleen
Aaron Auerbach, MD, MPH
40 Flow Cytometry
Nadine Aguilera, MD
46 Molecular Techniques
SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS
LYMPHOID HYPERPLASIA
54 Florid Follicular Hyperplasia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH
56 Autoimmune Disease
62 HIV in Spleen
68 Castleman Disease
70 Marginal Zone Hyperplasia
GRANULOMATOUS LESIONS/DISORDERS
72 Lipogranulomas
Jeffrey Vos, MD
78 Sarcoidosis
Ellina Hall, DO and Aaron Auerbach, MD, MPH
82 Chronic Granulomatous Disease
INFECTIONS
86 Mycobacteriosis
Nadine Aguilera, MD
90 Selected Bacterial Infections
Aaron Auerbach, MD, MPH
94 Candidiasis
96 Histoplasmosis
98 Cryptococcosis
100 Coccidioidomycosis
104 Pneumocystosis
108 Infectious Mononucleosis
112 Cytomegalovirus Infection
114 Herpes Simplex Virus Infection
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD
116 Echinococcosis
120 Malaria
NONINFECTIOUS CYSTS
122 Epithelial Cyst
124 False Cyst
NONNEOPLASTIC VASCULAR PROCESSES
126 Chronic Passive Congestion
128 Infarct
136 Peliosis
138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
RED CELL DISORDERS
144 Sickle Cell Disease
Aaron Auerbach, MD, MPH and Ellina Hall, DO
146 Thalassemia
Nadine Aguilera, MD and Aaron Auerbach, MD, MPH
150 Hereditary Spherocytosis
152 Thrombotic Thrombocytopenic Purpura
MISCELLANEOUS LESIONS/DISORDERS
158 Heterotaxy Syndromes
160 Congenital Splenic Abnormalities
164 Extramedullary Hematopoiesis
166 Gamna-Gandy Bodies
168 Hemophagocytic Lymphohistiocytosis
174 Immune Thrombocytopenic Purpura
178 Niemann-Pick Disease
Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD
184 Gaucher Disease
188 Sea-Blue (Ceroid) Histiocytosis
192 Gangliosidosis Lysosomal Disorder
194 Therapy Effect on Spleen
202 Traumatic and Nontraumatic Splenic Injuries
SECTION 3: NEOPLASTIC SPLENIC DISORDERS
BENIGN MESENCHYMAL LESIONS
208 Introduction to Vascular Lesions
210 Hemangioma
218 Lymphangioma
222 Littoral Cell Angioma
228 Inflammatory Pseudotumor
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
242 Splenic Hamartoma
246 Myelolipoma
MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS
248 Angiosarcoma
256 Hemangioendothelioma
258 Kaposi Sarcoma
260 Leiomyosarcoma
266 Gastrointestinal Stromal Tumor
272 Follicular Dendritic Cell Sarcoma
280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma
286 Langerhans Cell Histiocytosis
Guanghua Wang, MD
292 Histiocytic Sarcoma
LYMPHOMA
300 Introduction to Lymphoma
310 Splenic Marginal Zone Lymphoma
318 Hairy Cell Leukemia
326 Hairy Cell Leukemia Variant
334 Lymphoplasmacytic Lymphoma
342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
350 Follicular Lymphoma
358 Mantle Cell Lymphoma
366 Leukemic Nonnodal Mantle Cell Lymphoma
370 Splenic Diffuse Red Pulp B-Cell Lymphoma
376 B-Cell Prolymphocytic Leukemia
378 Diffuse Large B-Cell Lymphoma
384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst
390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
398 Burkitt Lymphoma
406 Classic Hodgkin Lymphoma
416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma
426 Peripheral T-Cell Lymphoma, Unspecified
432 Hepatosplenic T-Cell Lymphoma
440 T-Cell Prolymphocytic Leukemia
448 T-Cell Large Granular Lymphocytic Leukemia
456 Aggressive NK-Cell Leukemia
462 Transformation of Splenic Disorders
LEUKEMIA
466 Acute Myeloid Leukemia
474 Lymphoblastic Leukemia/Lymphoma
CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES
480 Myeloproliferative Neoplasm Overview
482 Chronic Myeloid Leukemia, BCR::ABL1 Positive
488 Essential Thrombocythemia
492 Polycythemia Vera
496 Primary Myelofibrosis
506 Mastocytosis
514 Chronic Myelomonocytic Leukemia
PLASMA CELL-ASSOCIATED DISORDERS
520 Amyloidosis
526 Heavy Chain Disease
530 Plasma Cell Myeloma/Plasmacytoma
METASTASIS
534 Metastatic Tumors
