Full Description
Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner."..a spectacular and seemingly comprehensive review of rheumatology." Reviewed by Dr. Harry Brown, on behalf of glycosmedia.com, December 2014Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation.Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field.Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.Access the full text online at Expert Consult.Fully revised, the new edition of the celebrated Hochberg is a must-have for every rheumatologist.
Contents
Section 11. Epidemiologic concepts and the classification of rheumatic and musculoskeletal conditions 2. Principles of clinical outcome assessment3. Principles of health economics and application to rheumatic disorders4. The synovium 5. The articular cartilage 6. Bone structure and function 7. Tendons and ligaments8. Connective tissue responses to mechanical stresses9. Biomechanics of peripheral joints10. Biomechanics of the spine 11. Principles of genetic epidemiology 12. Principles and techniques in molecular biology 13. Cytokines 14. Signal transduction in immune cells 15. The principles of adaptive immunity16. Principles of innate immunity 17. Systems biology 18. Epigenetics in Rheumatology 19. The microbiome in rheumatic diseases 20. Tissue destruction and repair 21. Principles of tissue engineering and cell- and gene-based therapy 22. Osteoimmunology 23. Inflammation and its mediators 24. Scientific basis of pain25. Effects of the neuroendocrine system on development and function of the immune system 26. Interpreting the medical literature for the rheumatologist: study design and levels of evidence27. Ethics in clinical trials Section 2: Clinical Basis of Rheumatic Disease28. History and physical examination29. Pattern recognition in arthritis30. Role of laboratory tests in rheumatic disorders 31. Synovial fluid analysis 32. Minimally invasive procedures 33. Skin in rheumatic disease 34. The eye in rheumatic disease 35. The heart in rheumatic disease 36. The lung in rheumatic disease 37. Gastrointestinal tract and rheumatic disease 38. The kidney and rheumatic disease 39. The nervous system in rheumatic diseaseSection 3: Evaluation: Imaging Techniques40. Conventional radiography and computed tomography41. Functional magnetic resonance imaging 42. Musculoskeletal ultrasound43. Bone scintigraphy and positron emission tomography 44. Dual x-ray absorptiometry and measurement of bone45. Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trialsSection 4: Principles of Management46. Arthritis patient education, health promotion, and team approaches to management 47. Principles of rehabilitation: physical and occupational therapy 48a. Complementary and alternative medicine 48b. Placebos, Caring and Healing in Rheumatology 49. Drug Development50. Non-pharmacologic pain management 51. Pharmacogenomics in rheumatology 52. Principles of opioid treatment of chronic musculoskeletal pain 53. Non-steroidal anti-inflammatory drugs54. Systemic glucocorticoids in rheumatology 55. Nonimmunosuppresive disease-modifying antirheumatic drugs56. Methotrexate 57. Leflunomide58. Immunosuppressives: cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil 59. T-cell costimulation and other directed therapies60. B-Cell depletion61. Cytokine neutralizers: interleukin-1 inhibitors62. Interleukin-6 Inhibition 63. Tumor necrosis factor blocking therapies64. Kinase inhibition: a new therapeutic principle in rheumatology65. Emerging therapeutic targets: GM-CSF, IL-17and IL-23 66. Biosimilars in Rheumatology67. Infections and biologic therapy in rheumatoid arthritis: an update on risk and prevention68. Drugs and pregnancy69. Aspiration and injection of joints and periarticular tissues and intralesional therapy 70. Perioperative care of patients with rheumatic diseaseSection 5: Regional and Widespread Pain71. Neck pain72. Lumbar spine disorders 73. The shoulder74. The elbow 75. The wrist and hand 76. The hip 77. The knee 78. The ankle and foot79. The temporomandibular joint 80. Fibromyalgia and related syndrome81. Entrapment neuropathies and compartment syndromes 82. Complex regional pain syndrome (reflex sympathetic dystrophy)Section 6: Rheumatoid Arthritis and Other Synovial Disorders83. Classification and epidemiology of rheumatoid arthritis 84. Preclinical features of rheumatoid arthritis 85. Clinical features of rheumatoid arthritis86. Extra-articular features of rheumatoid arthritis and systemic involvement 87. Adult-onset Still's disease 88. Imaging of rheumatoid arthritis89. The contribution of genetic factors to rheumatoid arthritis90. Animal models of arthritis91. Autoantibodies in rheumatoid arthritis92. Cellular immunity in rheumatoid arthritis93. Angiogenesis and vasculogenesis in rheumatoid arthritis 94. The rheumatoid joint: synovitis and tissue destruction 95. Evaluation and management of early inflammatory polyarthritis96. Evaluation and outcomes of patients with rheumatoid arthritis 97. Management of rheumatoid arthritis: synovitis 98. Multidisciplinary approach to rheumatoid arthritis Section 7: Pediatric Rheumatology99a. Evaluation of musculoskeletal complaints in children: clinical evaluation 99b. Evaluation of musculoskeletal complaints in children: non-inflammatory musculoskeletal disorders100. Classification and epidemiology of juvenile idiopathic arthritis101. Clinical Features of juvenile idiopathic arthritis 102. Etiology and pathogenesis of juvenile idiopathic arthritis103. Management of juvenile idiopathic arthritis 104. The juvenile-onset spondyloarthropathies105. Connective tissues diseases in children 106. Rehabilitation and psychosocial issues in juvenile idiopathic arthritis Section 8: Infection-Related Rheumatic Diseases107. Infectious Arthritis I: bacterial arthritis 108. Infectious Arthritis II: mycobacterium, brucella, fungal, and parasitic arthritis109. Lyme disease110. Rheumatologic aspects of viral infections 111. Acute rheumatic fever 112. Reactive arthritisSection 9: Spondyloarthropathies113. Classification and epidemiology of spondyloarthritis114. Clinical features of axial spondylarthritis115. Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis116. Genetics of axial spondyloarthritis 117. Imaging of spondyloarthritis 118. Management of ankylosing spondylitis/axial spondyloarthritis119. Classification and epidemiology of psoriatic arthritis120. Clinical features of psoriatic arthritis 121. Etiology and pathogenesis of psoriatic arthritis 122. Management of psoriatic arthritis 123. Enthesopathies Section 10: Connective Tissue Disorders124. Epidemiology and classification of systemic lupus erythematosus 125. Preclinical features of lupus126. Clinical features of systemic lupus erythematosus 127. Genetics of lupus 128. Immunopathology of systemic lupus erythematosus 129. Animal models of lupus130. Autoantibodies in systemic lupus erythematosus 131. Pathogenesis of lupus 132. Drug-induced lupus 133. Assessing disease activity and outcome in systemic lupus erythematosus 134. Management of non-renal/non-central nervous system lupus135. Treatment of neuropsychiatric lupus 136. Systemic lupus erythematosus: treatment-renal involvement 137. Systemic lupus erythematosus in the pregnant patient and neonatal lupus 138. Sj gren syndrome 139. Antiphospholipid syndrome: overview of pathogensis, diagnosis, and management 140. Classification and epidemiology of scleroderma 141. Assessing disease activity and outcome in systematic sclerosis (scleroderma)142. Clinical features of systemic sclerosis 143. Etiology and pathogenesis of systemic sclerosis 144. Management of systemic sclerosis 145. Pulmonary management of systemic sclerosis 146. Raynaud's phenomonen 147. Localized scleroderma and scleroderma-like syndromes148. Clinical features, classification, and epidemiology of inflammatory muscle disease 149. Inflammatory muscle disease-etiology and pathogenesis150. Management of inflammatory muscle disease151. Metabolic, drug-induced, and other non-inflammatory myopathies 152. Overlap syndromesSection 11: The Vasculitides153. Classification and epidemiology of vasculitis 154. Biology and immunopathogenesis of vasculitis155. Polyarteritis nodosa and Cogan's Syndrome 156. Polymyalgia rheumatica and giant cell arteritis 157. Antineutrophil cytoplasmic antibody-associated vasculitis 158. Takayasu's arteritis159. Beh et's syndrome 160. Kawasaki disease 161. Henoch-Sch nlein purpura/immunoglobulin-A vasculitis 162. Cutaneous vasculitis and panniculitis 163. Cryoglobulinemia 164. Primary angiitis of the central nervous systemSection 12: Other Systemic Illnesses165. Monogenic autoinflammatory diseases 166. Sarcoidosis167. Relapsing polychondritis 168. Amyloidosis169. Digital clubbing and hypertrophic osteoarthropathy 170. Miscellaneous arthropathies Section 13: Osteoarthritis and Related Disorders171. Osteoarthritis: epidemiology and classification 172. Local and systemic risk factors for incidence and progression of osteoarthritis 173. Clinical features of osteoarthritis174. Animal models of osteoarthritis 175. Pathogenesis and pathology of osteoarthritis 176. Genetics of osteoarthritis 177. Imaging of osteoarthritis 178. Assessment of the patient with osteoarthritis and measurement of outcomes 179. Preclinical osteoarthritis180. Assessment of imaging outcomes in osteoarthritis181. Management of osteoarthritis 182. Diffuse idiopathic skeletal hyperostosis183. Neuropathic arthropathy 184. Osteonecrosis 185. Rare Osteoarthritis: ochronosis and Kashin-Beck diseaseSection 14: Crystal-Related Arthropathies186. Epidemiology of gout187. Etiology and pathogenesis of gout 188. Clinical gout189. The management of gout and hyperuricemia190. Calcium pyrophosphate crystal-associated arthropathy 191. Basic calcium phosphate crystal deposition disease192. Other crystal-related arthropathies Section 15: Endocrine and Hemoglobin-Related Arthritis and Storage Diseases193. Rheumatoid manifestations of endocrine and lipid disease194. Hemophilia and von Willebrand disease195. Joint and bone lesions in hemoglobinopathies 196. HemochromatosisSection 16: Metabolic Bone Disease197. Epidemiology and classification of osteoporosis 198. Clinical features of osteoporosis199. Pathogenesis of osteoporosis 200. Biochemical markers in bone disease 201. Management of osteoporosis 202. Glucocorticoid-induced osteoporosis 203. Osteomalacia and rickets204. Primary hyperparathyroidism: rheumatologic manifestations and bone disease 205. Renal osteodystrophy206. Paget disease of boneSection 17: Heritable Disease and Tumors of Bone and Connective Tissue207. Gaucher disease 208. Mucopolysaccharidoses209. Heritable connective tissue disorders210. Hypermobility syndrome 211. Skeletal dysplasias212. Bone tumors
