薬物受容体の概念の歴史 A Short History of Drug Receptor (Science, Technology and Medicine in Modern History)

Prull, Cay-Rudiger/ Maehle, Andreas-Holger/ Halliwell, Robert Francis

Palgrave Macmillan（2009/08発売）

• 製本 Hardcover:ハードカバー版／ページ数 239 p.
• 言語 ENG
• 商品コード 9780230554153
• DDC分類 615.7

基本説明

This book is the first to consider the idea from its nineteenth century origins in the work Paul Ehrlich, to its current impact on drug discovery in the twenty-first century.

Full Description

The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century.

Contents

Introduction Paul Ehrlich and his Receptor Concept The Development of the Concept of Drug Receptors in the Physiological Research of J. N. Langley The Receptors and Scientific Pharmacology I: The Critics of the Receptor Idea and Alternative Theories of Drug Action, c. 1905-1935 The Receptors and Scientific Pharmacology II: The Critics of the Receptor Idea and Alternative Research Strands: The Transmitter Theory, c. 1905-1935 Quantitative Arguments for the Existence of Drug Receptors and the Development of the Receptor Occupancy Theory, c. 1910-1960 The Dual Adrenaline Receptor Theory of Raymond P. Ahlquist (1914-1983) and its Application in Drug Development between 1950 and 1970 The Emergence of Molecular Pharmacology Conclusions Archival Sources Bibliography