Full Description
Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreas transplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life.
This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation.
Contents
1. The history of pancreas transplantation ; 2. The nature of the problem: why do we need pancreatic transplantation? ; 3. Experimental models in whole organ pancreatic transplantation ; 4. Indications, patient evaluation and selection ; 5. Donor management and selection in pancreas transplantation ; 6. Procurement and benchwork preparation of the pancreatic graft ; 7. Pancreas preservation ; 8. Surgical techniques of pancreas transplantation ; 9. Immunosuppression for pancreas transplantation ; 10. Pancreatic rejection: histology, diagnosis and treatment ; 11. Surgical complications of pancreas transplantation ; 12. Medical and urological complications of pancreas and kidney/ pancreas transplantation ; 13. Post-transplant glucose intolerance ; 14. Long term metabolic and other consequences of pancreas and islet transplantation ; 15. Quality issues in pancreas transplantation ; 16. Pancreas transplantation using living donors ; 17. Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) ; 18. Insulin Gene Therapy ; 19. A historical view for the development of cellular and islet transplantation ; 20. Fetal and neonatal pancreatic tissue transplantation ; 21. Experimental approaches to the prevention of islet rejection ; 22. Suitable donor selection, techniques of islet isolation and purification for human islet allograft transplantation ; 23. Outcomes and clinical effectiveness of islet transplantation ; 24. Islet auto-transplantation ; 25. Approaches to immunological tolerance and potential application in pancreatic islet transplantation ; 26. History of pancreatic stem cell transplantation and alternative islet sources ; 27. Stem cell therapy for the treatment of diabetes ; 28. Future challenges in Beta cell replacement therapies ; 29. Beta cell regenearation in the post-natal pancreas ; 30. Gene and stem cell therapy for diabetes
