From Molecules to Living Organisms: An Interplay between Biology and Physics : Lecture Notes of the Les Houches School of Physics: Volume 102, July 2014 (Lecture Notes of the Les Houches Summer School)

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From Molecules to Living Organisms: An Interplay between Biology and Physics : Lecture Notes of the Les Houches School of Physics: Volume 102, July 2014 (Lecture Notes of the Les Houches Summer School)

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  • 製本 Hardcover:ハードカバー版／ページ数 464 p.
  • 言語 ENG
  • 商品コード 9780198752950
  • DDC分類 570

Full Description

The book gathers lecture notes of courses given at the 2014 summer school on integrated biology in Les Houches, France, Session CII. It addresses an emerging field ranging from molecules to cells and to organisms. Through examples it presents a new way of thinking using a combination of interdisciplinary and cutting-edge methods, bridging physics and biology beyond current biophysics. Important novel developments are expected in the coming years that may well introduce paradigm shifts in biological science. The school had the ambition to prepare participants to become major actors in these breakthroughs.

The power of integrated approaches is illustrated through two cases: interactions between viruses and host cells, and flower development. The role of forces in biology, as well as their mathematical modeling, is illustrated in both processes: how they allow flower organs to emerge or how they control membrane fusion during virus budding. The book also underlines the importance of conformational changes and dynamics of proteins particularly during membrane processes. It explains how membrane proteins can be handled and studied by molecular simulations. Finally, the book also contains concepts in cell biology, in thermodynamics and several novel approaches such as in-cell NMR. Altogether, the chapters show how examining a biological system from different viewpoints based on multidisciplinary aspects often leads to enriching controversial arguments.

Contents

PART I: CONCEPTS IN CELL BIOLOGY AND EXAMPLES OF MULTISCALE STUDIES IN BIOLOGY; PART II: CONCEPTS IN PHYSICS AND EMERGING METHODS; PART III: PLANT DEVELOPMENT: FROM GENES TO GROWTH; PART IV: FORCES IN BIOLOGY: RESHAPING MEMBRANES; PART V: CONFORMATIONAL CHANGES AND THEIR IMPLICATIONS IN DISEASES; PART VI: MEMBRANE TRANSPORTERS: FROM STRUCTURE TO FUNCTION