Full Description
Frontotemporal Dementia provides an in-depth look at the history, various types, genetics, neuropathology and psychosocial aspects of one of the most common but least understood causes of dementia, frontotemporal lobar degeneration, from one of the world's leading centers for the study of dementia. Aided by the latest research in diagnosis, mechanism and treatment, this book captures the rich and quickly changing landscape of a devastating neurodegenerative disease, and offers up-to-date clinical advice for patient care. Frontotemporal dementia, in particular, raises psychological and philosophical questions about the nature of self, free will, emotion, art and behavior - important topics for practitioners and families to appreciate as they care for the sufferer. This book includes case studies, photographs and figures from the leaders in the field and personal communication from the researchers driving these developments.
Contents
Table of Contents ; 1. History and Nomenclature ; Pick's Disease: The Contributions of Arnold Pick ; Maintaining Early Traditions and Refining Diagnosis: Delay, Brion, Escourolle, Malamud and Constantinidis ; Splintering of Pick's Disease into Multiple Subtypes ; The Biological Revolution ; FTD Now: Where Are We? ; The Future ; References ; 2. The Clinical Syndrome of bvFTD ; Overview ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; BVFTD: Current State And Research Advances ; References ; 3.The Clinical Syndrome of NFVPPA ; Overview ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; NFVPPA: Current State And Research Advances ; References ; Related Disorders: FTD-ALS ; Overview ; Amyotrophic Lateral Sclerosis ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; FTD-ALS: Current State and Research Advances ; References ; 6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy ; Overview ; Creativity ; Treatment ; svPPA: Current State and Research Advances ; Semantic Knowledge and the Anterior Temporal Lobes ; Autoimmunity, Left-Handedness, Head Trauma and svPPA ; Summary ; References ; 4. Progressive Nonfluent/Agrammatic Aphasia ; Overview ; Case History ; Comment ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; nfvPPA: Current State and Research Advances ; Diagnosis from Clinical Syndrome to Molecular Diagnosis ; Neurolinguistic and Neuroplasticity Discoveries ; References ; 5. Related Disorders: FTD-ALS ; Overview ; Amyotrophic Lateral Sclerosis ; Case History ; Comment ; Clinical Features and Anatomy ; El Escorial Criteria ; Genetic and Pathological Correlates ; Neuropathology ; Differential Diagnosis ; Treatment ; FTD-ALS: Current State and Research Advances ; Clinical-Pathological Considerations ; Molecular Considerations ; References ; 6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy ; Overview ; Corticobasal Degeneration (CBD) ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; Progressive Supranuclear Palsy (PSP) ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; CBD and PSP: Current State and Research Advances ; References ; 7. A Primer of FTLD Neuropathology ; General Features ; Overview of Tau-Related Neuropathology in FTLD ; Overview of TDP-43 and FUS Related Neuropathology in FTLD ; Gross Anatomical and Microscopic Changes in FTLD ; Special Features of FTLD Pathology ; FTLD Neuropatholoy: Current State and Research Advances ; 8. FTD Genes ; Overview ; Genes Implicated in FTD ; Genes That Modify FTD Expression ; Management and Genetic Counseling ; References ; 9. FTD Reflections Upon Psychology and Philosophy ; Emotions ; The Self ; Free Will ; Religious Beliefs ; Psychology ; von Economo Neurons ; References ; 10. Treatments ; Diagnosis ; bvFTD: Targeting Symptoms, Educating the Family ; svPPA: Targeting Symptoms, Educating the Family ; nfvPPA: Targeting Symptoms and Educating the Family ; Late Stages of FTD ; Early Interventions ; Pharmacological Review ; Non-Pharmacological Therapies ; Complementary and Alternative Medicine ; Language Impairment ; Future Treatments ; Conclusions ; References
