基本説明
Provides guidelines for diagnosis and treatment of both symptoms and the underlying disease process, as well as updates on current basic science and research initiatives.
Full Description
Primer on Multiple Sclerosis was developed to provide a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS. The reader is provided with the latest information on the science of MS, including immunology, genetics, epidemiology and pathology, as well as a summary of the newest directions
in basic science research. Guidelines for diagnosis and appropriate use of diagnostic modalities are presented. All clinical aspects of MS are discussed, including extensive information on aspects that may be more challenging for the neurologist to manage, such as sleep disorders and pain.
Disease modifying therapies, including those that are FDA approved, as well as off label and experimental therapies are discussed. Finally, there are chapters on employment and legal issues, as well as an overview of clinical trials and clinical trial outcome measures, which are helpful in reviewing the scientific literature in these areas.
Contents
Contributors
Chapter 1: The History of Multiple Sclerosis: From the Age of Description to the Age of Therapy
T. Jock Murray
Part 1: Basic Science
Chapter 2: Genetics and Epidemiology in Multiple Sclerosis
Sreeram V. Ramagopalan and A. Dessa Sadovnick
Chapter 3: Neurophysiology of Multiple Sclerosis
Jefferson C. Slimp
Chapter 4: Immunology of Multiple Sclerosis
Laura Piccio and Anne H. Cross
Chapter 5: Taking a Microscopic Look at Multiple Sclerosis
Claudia F. Lucchinetti
Part 2: Diagnosis and Prognosis
Chapter 6: Diagnosis of Multiple Sclerosis
Loren A. Rolak
Chapter 7: Neuroimaging in Multiple Sclerosis
Nancy L. Sicotte
Chapter 8: Cerebrospinal Fluid Profile Supporting a Clinical Definite Multiple Sclerosis Diagnosis
Wallace W. Tourtellotte
Chapter 9: Evoked Potentials
Marc R. Nuwer
Chapter 10: Temporal and Clinical Course of Multiple Sclerosis
Erica Grazioli, Cornelia Mihai, and Bianca Weinstock-Guttman
Chapter 11: Outcome Measures in Multiple Sclerosis
Robert M. Herndon
Part 3: Clinical Manifestations
Chapter 12: Neuro-Ophthalmologic Manifestations of Multiple Sclerosis
Erik V. Burton and Elliot M. Frohman
Chapter 13: Disorders of Mobility in Multiple Sclerosis
Thomas E. McNalley and Jodie K. Haselkorn
Chapter 14: Multiple Sclerosis and Pain
Norman S. Namerow
Chapter 15: Management of Urinary and Bowel Dysfunction in Patients with Multiple Sclerosis
Ja-Hong Kim
Chapter 16: Assessment and Treatment of Sexual Dysfunction in Multiple Sclerosis
Frederick W. Foley
Chapter 17: Gender and Reproductive Issues in Multiple Sclerosis
Rhonda Voskuhl
Chapter 18: Cerebellar and Brainstem Dysfunction in Multiple Sclerosis
Angeli S. Mayadev and George H. Kraft
Chapter 19: Cognitive Impairment and Mood Disturbances
Nicholas G. LaRocca
Chapter 20: Fatigue in Multiple Sclerosis
Christopher Christodoulou, Yashma Patel, and Lauren Krupp
Chapter 21: Sleep Disorders in Multiple Sclerosis
Tiffany Braley and Alon Y. Avidan
Chapter 22: Pediatric Multiple Sclerosis
E. Ann Yeh, Tanuja Chitnis, Lauren Krupp, Jayne M. Ness, Dorothee E. Chabas, Nancy Kuntz, and Emmanuelle L. Waubant
Part 4: Therapeutics
Chapter 23: Immunomodulatory Agents for Relapsing-Remitting Multiple Sclerosis
Lawrence M. Samkoff
Chapter 24: Immunosuppressive and Novel Therapies
Barbara S. Giesser
Chapter 25: Complementary and Alternative Medicine in Multiple Sclerosis
Allen C. Bowling
Part 5: Psychosocial Issues
Chapter 26: Living with Multiple Sclerosis: The Psychosocial Challenges for Patients and Their Families Rosalind C. Kalb
Chapter 27: Employment and Career Development Considerations
Phillip D. Rumrill, Jr. and Steven W. Nissen
Chapter 28: Legal Planning Issues
Laura D. Cooper, Esq.
Part 6: Research
Chapter 29: Issues in the Design and Interpretation of Multiple Sclerosis Clinical Trials
Stephen Krieger, Svenja Oynhausen, and Aaron Miller
Chapter 30: Basic Science in Multiple Sclerosis: Progress and Promise
Wendy Gilmore and Leslie P. Weiner
Index
