基本説明
Contains chapters from experts in the fields of brain imaging, clinical neuroscience, and cognitive neuroscience who have studied the aging brain.
Full Description
This book contains chapters from experts in the fields of brain imaging, clinical neuroscience, and cognitive neuroscience who have studied the aging brain. Topics covered include technical factors in brain imaging, pathological basis of age-related structural and functional changes, neurochemistry and genetics of brain imaging in aging, and the use of imaging techniques in diagnosis, longitudinal testing, drug development and testing, and presymptomatic detection. The book is intended to be both a detailed review of the current status of brain imaging and aging and to serve as an introduction to the field for those who may be starting investigations using imaging techniques of PET, structural MRI, and functional MRI. It covers basic science approaches such as using fMRI to probe networks, as well as recent developments like amyloid imaging and the use of imaging as a biomarker in clinical trials.
Contents
1. Introduction: Still More Questions than Answers
William Jagust and Mark D'Esposito
2. Methodological and Conceptual Issues in the Study of the Aging Brain
Mark D'Esposito, William Jagust and Adam H. Gazzaley
3. Neuropathology of Aging
Dara L. Dickstein, John H. Morrison and Patrick R. Hof
Basic Science
4. A Systems Approach to Age-Related Change: Neuroanatomic Changes, Their Modifiers, and Cognitive Correlates
Naftali Raz and Kristen M. Kennedy
5. Dopaminergic Modulation of Cognition in Human Aging
Shu-Chen Li, Ulman Lindenberger, Lars Nyberg, Hauke R. Heekeren, and Lars Backman
6. Cognitive Reserve
Yaakov Stern
7. Compensatory Reorganization of Brain Networks in Older Adults
Cheryl L. Grady
8. Cross-species Imaging Applied to the Aging Brain: Dissociating Alzheimer's Disease From Normal Aging
Scott A. Small and Sidonie Jones
9. Genetics and Imaging in Alzheimer's Disease
Susan Y. Bookheimer
Clinical Applications
10. Imaging Cognitive Decline in Aging: Predicting Decline with Structural Imaging
Jeffrey Kaye
11. The Early Detection of Alzheimer's Disease with Positron Emission Tomography
Rachel Mistur, Lisa Mosconi, Remigiusz Switalski, Susan De Santi, Yi Li, Lisa Glodzik-Sobanska, Miroslaw Brys, Wai Tsui, Henry Rusinek, Mony de Leon
12. Structural Imaging of Mild Cognitive Impairment
Clifford R. Jack, Jr.
13. Functional Imaging with FDG-PET in Mild Cognitive Impairment
Karl Herholz
14. Amyloid Imaging and (What is "Normal") Aging
William E. Klunk and Chester A. Mathis
15. Differential Diagnosis of Dementia using Functional Neuroimaging
Eric Salmon, Fabienne Collette, and Gaetan Garraux
16. MRI and the Differential Diagnosis of Dementia
António J. Bastos-Leite and Philip Scheltens
17. White Matter Hyperintensities in Aging and Dementia
Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli
18. Functional MRI Studies in Aging and Early Alzheimer's Disease: Predicting Clinical Decline
Reisa Sperling and Harald Hampel
19. MRI as a Surrogate Marker in Clinical Trials in Alzheimer's Disease
Frank Jessen and Harald Hampel
20. Brain Imaging in the Evaluation of Putative Alzheimer's Disease Slowing, Risk-Reducing, and Prevention Therapies
Eric M. Reiman and Jessica B.S. Langbaum
21. Databasing the Aging Brain
John Darrell Van Horn and Arthur W. Toga
