Full Description
Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.
Contents
Chapter 1: Contribution of Epidemiology to Our Understanding of Psychiatric Genetics
Alison K. Merikangas and Kathleen R. Merikangas
Chapter 2: Recruitment of Human Subjects: An overview of techniques and methods used in psychiatric and other clinical studies
Layla Kassem
Chapter 3: Basic molecular genetics concepts and tools: from SNPs to chips
Sevilla D Detera-Wadleigh, Nirmala Akula, and Liping Hou
Chapter 4: Statistical genetics: Genome-wide studies
Till F.M. Andlauer, Bertram Müller-Myhsok, and Stephan Ripke
Chapter 5: Human Linkage and Association Analysis
John P. Rice
Chapter 6: The role of copy number variation in psychiatric disorders
Elliott Rees and George Kirov
Chapter 7: Pharmacogenomics & Precision Psychiatry
Julia C. Stingl and Gonzalo Laje
Chapter 8. Endophenotypes
David C. Glahn, Laura Almasy, and John Blangero
Chapter 9: Imaging Genetics
Luanna Dixson, Heike Tost, and Andreas Meyer-Lindenberg
Chapter 10: Bioinformatics in psychiatric genetics
Nikola S. Mueller, Ivan Kondofersky, Gökcen Eraslan, Karolina Worf, and Fabian J. Theis
Chapter 11: Epigenomic Exploration of the Human Brain
Tobias B. Halene, Gregor Hasler, Amanda Mitchell, and Schahram Akbarian
Chapter 12: Epigenetics in Psychiatry
Subha Subramanian and James B. Potash
Chapter 13: Next-generation sequencing in genetic studies of psychiatric disorders
Shweta Ramdas and Jun Z. Li
Chapter 14: Animal Models
Tadafumi Kato
Chapter 15: Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research
Jennifer C. Moore, Michael Sheldon, and Jay A. Tischfield
