Full Description
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.
Contents
Chapter 1 Historical Perspective 1Chapter 2 Chromatin Dynamics and Chromatin Remodeling in Animals 19Chapter 3 Chromatin Dynamics and Chromatin Remodeling in Plants 49Chapter 4 DNA Methylation as Epigenetic Mechanism 75Chapter 5 Histone Modifications and Their Role in Epigenetic Regulation 119Chapter 6 Realm of Non-Coding RNAs--From Bacteria to Human 147Chapter 7 Non-Coding RNAs Involved in Epigenetic Processes--A General Overview 177Chapter 8 Non-Coding RNAs Across the Kingdoms--Bacteria and Archaea 203Chapter 9 Non-Coding RNAs Across the Kingdoms--Protista and Fungi 223Chapter 10 Non-Coding RNAs Across the Kingdoms--Animals 267Chapter 11 Non-Coding RNAs Across the Kingdoms--Plants 297Chapter 12 Non-Coding RNAs--Comparison of Biogenesis in Plants and Animals 327Chapter 13 Paramutation, Transactivation, Transvection, and Cosuppression--Silencing of Homologous Sequences 343Chapter 14 Bacterial Adaptive Immunity--Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 385Chapter 15 Gene Silencing--Ancient Immune Response and a Versatile Mechanism of Control over the Fate of Foreign Nucleic Acids 409Chapter 16 Epigenetics of Germline and Epigenetic Memory 435Chapter 17 Epigenetics of Health and Disease--Cancer 465Chapter 18 Epigenetics of Health and Disease--Behavioral Neuroscience 499Chapter 19 Epigenetics of Health and Disease--Diet and Toxicology, Environmental Exposures 523Chapter 20 Epigenetics and Technology--Hairpin-Based Antisensing 555Index 577
