Full Description
Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.
Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.
Contents
1. Organ transplantation: past, present, and future
2. Trends in kidney transplantation
3. Immunobiology in kidney transplantation
4. Immunosuppression in kidney transplantation
5. Challenges in the therapeutic drug monitoring of immunosuppressants
6. Overview of biomarkers in kidney transplantation
7. Biomarkers for ischemia reperfusion injury and delayed graft function
8. Biomarkers of renal transplant rejection: yesterday, today, and tomorrow
9. Biomarkers predicting the response to immunosuppressant therapy
10. Biomarkers of recurrent disease after kidney transplantation
11. Biomarkers of tolerance in renal transplantation
12. Biomarkers for detecting opportunistic infections in renal transplant recipients
13. Biomarkers for detecting nephrotoxicity due to immunosuppressant drugs
14. Biomarkers for drug development in kidney transplantation
15. Commercially available biomarker tests in kidney transplantation
16. The unmet needs, current challenges and future directions for biomarkers in renal transplantation
