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Full Description
Recent Advances in iPSC Disease Modeling, Volume One addresses how induced pluripotent stem cells can be used to model various diseases. This new volume teaches readers about current advances in the field, describing the use of induced pluripotent stem cells to model several diseases in vitro, and thus enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development and progression. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation specialists.
In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. Hence, these advantages have facilitated the identification of key targets and further defining on the molecular basis of several disorders.
Contents
1. iPSCs for Modeling Lysosomal Storage Diseases
2. Sickle Cell Anemia: HBB Haplotypes; Clinical Heterogeneity; iPSC Modelling
3. iPSCs for Modeling mtDNA Diseases
4. iPSCs for Modeling Diamond Blackfan Anemia
5. Modeling Severe Congenital Neutropenia in Induced Pluripotent Stem Cells
6. iPSCs for Modeling Duchenne Muscular Dystrophy
7. Induced Pluripotent Stem Cell Modelling of Genetic Small Vessel Disease
8. The Contribution of Human Pluripotent Stem Cells to the Study of Myotonic Dystrophy Type 1
9. Induced Pluripotent Stem Cells (iPSCs) for Modeling of Bernard-Soulier Syndrome
10. iPSCs for Modelling Familial Hypercholesterolemia Type II A
11. iPSCs for Modeling Elastin-Associated Vasculopathy
12. iPSCs for Modeling of Sarcomeric Cardiomyopathies
13. Werner Syndrome iPS Cell, A Study of Pathologic Aging
