Full Description
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.
Contents
Part 1. Fundamentals of quadruplexes and their biology
Fundamentals of G-quadruplex biology
F. Brad Johnson
Quadruplex structure and diversity
Fernaldo Richtia Winnerdy and Anh Tuân Phan
Part 2. Quadruplex targets in human and other organisms
Telomeric quadruplexes as therapeutic targets
Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama
Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy
Emanuela Ruggiero and Sara N. Richter
Quadruplex detection in human cells
David Monchaud
Part 3. Discovery and design of quadruplex-binding compounds
An overview of quadruplex ligands: Their common features and chemotype diversity
Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria
Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding
Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider
Quadruplex-interacting compounds for regulating the translation of the Epstein-Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers
Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou
Click and combinatorial approaches to quadruplex ligand discovery
Jyotirmayee Dash, Puja Saha and Khushnood Fatma
Quadruplex nucleic acids in KRAS targeted-cancer therapy
Luigi E. Xodo
Transcriptional regulation of MYC through G-quadruplex structures
Sumirtha Balaratnam and John S. Schneekloth
KIT promoter: Structure, function and targeting
Silvia Ceschi and Claudia Sissi
Quadruplex targets in neurodegenerative diseases
Janez Plavec
Metal complexes as G-quadruplex binders
Tim Kench and Ramon Vilar
Challenges in developing small-molecule quadruplex therapeutics
Stephen Neidle
