Full Description
Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.
Contents
1. Introduction to Clinical Pharmacology
Arthur John Atkinson Jr., Juan J. L. Lertora and Shiew Mei Huang
2. Clinical Pharmacokinetics
Arthur John Atkinson Jr.
3. Compartmental Analysis of Drug Distribution
Arthur John Atkinson Jr.
4. Drug Absorption and Bioavailability
Arthur John Atkinson Jr.
5. Effect of Renal Disease on Pharmacokinetics
Thomas D. Nolin, Albert Dreisbach and Juan J. L. Lertora
6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy
Arthur John Atkinson Jr., Thomas D. Nolin and John Allen
7. Effect of Liver Disease on Pharmacokinetics
Juan J. L. Lertora, Robert A. Branch and Nathalie K. Zgheib
8. Non-Compartmental and Compartmental Approaches to Pharmacokinetic Data Analysis
Paolo Vicini
9. Population Pharmacokinetics
Raymond Miller and Ophelia Yin
10. Pathways of Drug Metabolism
Nina Isoherranen and R. Scott Obach
11. Methods of Analysis of Drugs and Drug Metabolites
Mark Edward Arnold and Brian Booth
12. Clinical Pharmacogenomics
Anuradha Ramamoorthy, Tristan Sissung and Michael Pacanowski
13. Mechanisms and genetics of drug transport
Lei Zhang, Sook Wah Yee, Osatohanmwen Enogieru, Shiew Mei Huang and Kathleen Giacomini
14. drug-drug interactions
Aleksandra Galetin, Lei Zhang, A. David Rodrigues and Shiew Mei Huang
15. Biochemical Mechanisms of Drug Toxicity
Arthur John Atkinson Jr., Jack Uetrecht, Denis M. Grant and Peter G. Wells
16. pharmacogenomic mechanisms of drug toxicity
Shiew Mei Huang, Ligong Chen and Kathleen Giacomini
17. Biomarkers in Drug Development
Robert N. Schuck, Jana G. Delfino, Christopher Leptak and John A. Wagner
18. imaging in drug development
Owen Carmichael
19. dose-effect and concentration-effect analysis
Juan J. L. Lertora, Yaning Wang, Jiang Liu and Justin C. Earp
20. time course of drug response
Nick Holford
21. disease progress models
Diane Renee Mould, Nick Holford and Carl Peck
22. Pharmacological Differences between Men and Women
Mary F. Paine and Karen Dinh Vo
23. drug therapy in pregnant and nursing women
Catherine Stika and Marilynn C. Frederiksen
24. pediatric clinical pharmacology and therapeutics
Bridgette Jones, John N. van den Anker, Gilbert J. Burckart and Gregory Kearns
25. Medication Therapy in Older Adults
S. W. Johnny Lau, Danijela Gnjidic and Darrell Abernethy
26. clinical analysis of adverse drug reactions
Christine Chamberlain, Cindy Kortepeter and Monica Munoz
27. Quality Assessment of Drug Therapy
Charles Edward Daniels
28. portfolio and project planning and management in the drug discovery evaluation, development, and regulatory review process
Charles V. Grudzinskas, Michael Dyszel, Khushboo Sharma and Charles T. Gombar
29. Drug Discovery
Thomas Bateman
30. Non-Clinical Drug Development
Chris H. Takimoto
31. pre-clinical prediction of human pharmacokinetics
Malcolm Rowland
32. Phase I Clinical Studies
Robert Joseph Noveck and Martina D. Sahre
33. pharmacokinetic and pharmacodynamic considerations in the development of biotechnology products and large molecules
Pamela Garzone and Yow-Ming C. Wang
34. Design of Clinical Development Programs
Megan Gibbs, Bengt Hamren, Helen Tomkinson, Renee Bailey Iacona and David Boulton
35. the role of the FDA in guiding drug development;
Elimika Pfuma Fletcher, Rajanikanth Madabushi, Chandrahas Sahajwalla, Lawrence J. Lesko and Shiew Mei Huang
36. Emerging Clinical Pharmacology Topics in Drug Development and Precision Medicine
Qi Liu, Jack A. Gilbert, Hao Zhu, Shiew Mei Huang, Elizabeth Kunkoski, Promi Das, Kimberly Bergman, Mary Buschmann and M Khair ElZarrad
Appendix I
Appendix II
