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Full Description
**Selected for Doody's Core Titles® 2024 in Clinical Genetics**
Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues.
Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.
Contents
1. Genomics and psychiatry: a historical overview
2. Schizophrenia genomics
3. Genetics of bipolar disorder
4. Genetics of depression
5. Genetics of personality disorders
6. Genomics and epigenomics of anxiety and obsessive-compulsive disorders
7. Neurogenetics of alcohol use disorder a subset of reward deficiency syndrome: candidate genes to be or not to be?
8. Pharmacogenomics and antipsychotics: efficacy and adverse drug reactions
9. Pharmacogenomics and antidepressants: efficacy and adverse drug reactions
10. Pharmacogenomics and mood stabilizers: efficacy and adverse drug reactions
11. Balancing prevention and respect: the ethical stakes of a psychiatric genomics lens for mental disorder and intellectual disability
12. Genetic animal models for psychiatric disorders
13. Psychiatric genomics: brain pathophysiology and genetic factors
14. Integration with systems biology approaches and -omics data to characterize risk variation
15. Usage of biobank data for psychiatric genomics and promotion of precision psychiatry
16. Shared heritability among psychiatric disorders and traits
17. Endophenotypes in psychiatric genomics: a selective review of their status and a call to action
