Full Description
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.
Contents
Foreword
Melvin Andersen
Preface
Jeffrey W. Fisher, Zhoumeng Lin and Jeffery M. Gearhart
1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topics
Zhoumeng Lin and Jeffrey W. Fisher
2. Introduction to classical pharmacokinetics
Shruti V. Kabadi and Zhoumeng Lin
3. Fundamentals of physiologically based pharmacokinetic modeling
Jeff Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand and Zhoumeng Lin
4. Physiologically based pharmacokinetic modeling software
C.E. Hack, A.Y. Efremenko, S.N. Pendse, C.A. Ellison, A. Najjar, N. Hewitt, A. Schepky and H.J. Clewell III
5. Chemical absorption and writing code for portals of entry
Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr and Darshan Mehta
6. Physiologically based pharmacokinetic model: distribution processes
Christopher Ruark
7. Metabolism and physiologically based pharmacokinetic models
Jeffrey W. Fisher, Jerry L. Campbell Jr. and Zhoumeng Lin
8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breath
Sami Haddad and Andy Nong
9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis
Tammie R. Covington and Jeffery M. Gearhart
10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment
Zhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou and Miao Li
11. Examples of physiologically based pharmacokinetic modeling applied to risk assessment
Lisa M. Sweeney and Jeffery M. Gearhart
12. Physiologically based pharmacokinetic models to support modernized chemical safety assessment
Miyoung Yoon
