Full Description
Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function.
Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource.
Contents
PART I: Platelet Biology
1. The Evolution of Mammalian Platelets
2. Megakaryocyte Development and Platelet Formation
3. The Structure of Resting and Activated Platelets
4. Platelet Glycobiology and the Control of Platelet Function and Lifespan
5. Platelet Genomics
6. Platelet MicroRNAs
7. The Platelet Transcriptome in Health and Disease
8. The Platelet Proteome
9. Platelet Receptors
10. The Glycoprotein Ib-IX-V Complex
11. GPVI and CLEC-2
12. Integrin αIIbβ3
13. Protease-Activated Receptors
14. The Platelet P2 Receptors
15. Platelet Inhibitory Receptors
16. Interactions Between Platelets, Leukocytes, and the Endothelium
17. Inhibition of Platelet Function by the Endothelium
18. Platelet Signal Transduction
19. Platelet Secretion
20. Hemostatic Thrombus Formation in Flowing Blood
21. Interactions Between Platelets and the Coagulation System
22. Platelet-Derived Extracellular Vesicles
23. Regulation of Fibrinolysis by Platelets
24. The Role of Platelets in Angiogenesis
25. Platelet Function in the Newborn
PART II: The Role of Platelets in Disease
26. The Role of Platelets in Atherothrombosis
27. The Role of Platelets in Diabetes Mellitus
28. The Role of Platelets in Inflammation
29. The Role of Platelets in Antimicrobial Host Defense
30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion
31. The Role of Platelets in Sickle Cell Disease
PART III: Clinical Tests of Platelet Function
32. Platelet Counting
33. Clinical Tests of Platelet Function
34. Platelet Aggregation
35. Flow Cytometry
36. Laboratory Monitoring of Antiplatelet Therapy
37. Platelet Function Testing in Clinical Research Trials
PART IV: Disorders of Platelet Number and/or Function
38. The Clinical Approach to Disorders of Platelet Number and Function
39. Immune Thrombocytopenia (ITP)
40. Drug-Induced Thrombocytopenia
41. Heparin-Induced Thrombocytopenia
42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes
43. Thrombocytopenia in Pregnancy
44. Thrombocytopenia in the Newborn
45. Alloimmune Thrombocytopenia
46. Inherited Thrombocytopenias
47. Thrombocytosis and Essential Thrombocythemia
48. Inherited Disorders of Platelet Function
49. Acquired Disorders of Platelet Function
PART V: Antiplatelet Therapy
50. Aspirin
51. P2Y12 Antagonists
52. αIIbβ3 (GPIIb-IIIa) Antagonists
53. PAR-1 Antagonists
54. Phosphodiesterase Inhibitors
55. Novel Antiplatelet Therapies
56. Antiplatelet Drugs in the Management of Coronary Artery Disease
57. Antiplatelet Drugs in the Management of Cerebral Ischemia
58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease
59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications
60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Children
PART VI: Therapy to Increase Platelet Numbers and/or Function
61. Thrombopoietin Receptor Agonists
62. Desmopressin (DDAVP)
63. Factor VIIa
64. Platelet Transfusion Medicine
65. Therapeutic Platelet-Rich Plasma in Wound Healing
66. Stem Cell-Derived Platelets
67. Gene Therapy for Platelet Disorders
