Full Description
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource.
Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians.
Contents
Part I - Basic FeaturesSection I - Structure1. Vascular Endothelium: a perspective2. Development of the coronary system: perspectives for cellular therapy from differentiaton of its precursors3. Translational pathways in endothelial cell: Implications for angiogenesis4. Endothelial barrier: factors that regulate its permeability5. Growth factors, endothelial progenitor cells and angiogenesis6. Characteristics of Endothelium in both sexes
Section II - Endocrine functions and metabolic interactions7. Hemodynamic forces in the Endothelium: from mechanical transduction to atherosclerosis development8. Endothelium dependent vasodilation: NO and other mediators9. Endothelial vasoconstrictor substances produced by the endothelium10. Cellular redox pathways in endothelial dysfunction and vascular diseases 11. Blood coagulation and Endothelium12. Genetics of Endothelium 13. Epigenetic regulation of endothelial function12. Adhesion molecules and the Endothelium15. Endothelium and Renin-Angiotensin System
Part II - Endothelial Dysfunction and Clinical SyndromesSection III - Methods of investigation16. Methods for endothelial function investigations in humans17. Endothelial biomarkers
Section IV - Aging and cognitive function18. Endothelial alterations in aging19. Vascular function in dementia and cognitive decline20. Emotional stress and its influence upon the Endothelium
Section V - Lipoproteins21. Lipids and lipoprotein mediators of endothelial function and dysfunction22. HDL and Endothelium23. Artificial lipoproteins in endothelial dysfunction and atherosclerosis
Section VI - Diets and Endothelium24. Influences of diets upon endothelial function25. Effects of Mediterranean diet upon endothelial function26. Effects of red wine and polyphenols upon endothelial function and clinical events
Section VII - Kidney and hypertensive diseases27. Kidney and the Endothelium28. Endothelium and arterial hypertension29. Endothelial alterations in pulmonary hypertension
Section VIII - Atherosclerosis and Coronary Artery Disease30. Endothelial alterations in chronic coronary disease31. Molecular mechanisms of the arterial wall in acute coronary syndromes32. Endothelium: coordinator of acute and chronic inflammation33. Endothelium in atherosclerosis: plaque formation and its complications34. Risk factors and endothelial dysfunctions35. Sleep disturbances and endothelial dysfunction36. Smoking and Endothelium: Endothelial dysfunction and microcirculation in women with angina and normal coronaries
Section IX - Heart Failure37. Endothelial alterations in heart failure: mechanisms and molecular basis38. Heart Failure: influences of drug intervention upon vessels
Section X - Percutaneous Coronary Interventions and Cardiac Surgery39. Endothelial repair after percutaneous intervention40. Stents and Endothelium41. Vascular disease of the transplanted heart: physiopathology and therapeutic options
Section XI - Metabolic Syndromes42. Erectile dysfunction and endothelium43. Obesity, Diabetes and Endothelium: molecular interactions
Section XII -- Non-Cardiovascular Diseases and Endothelium44. Endothelial mechanisms in pre-eclampsia45. Endothelium and nitric oxide: interactions in cancer evolution46. Endothelial function and skin microcirculation
Section XIII - Treatment Options in Endothelial Dysfunction47. Endothelial dysfunction in the clinical setting: prognosis and therapeutic target48. Physical exercise and the Endothelium49. Endothelium and immunologic alterations in atherosclerosis
